BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Memento EPFL//
BEGIN:VEVENT
SUMMARY:EPFL BioE Talks SERIES  "Programmable Protein Therapeutics via Gen
 erative Language Models"
DTSTART:20250520T141500
DTEND:20250520T151500
DTSTAMP:20260406T125532Z
UID:00f4f1f6fa50b1ea22a107a567cbc9dd6b0049c37a3bb701765966f7
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Pranam Chatterjee\, Duke University\, Durham\, NC (USA)\
 nWEEKLY EPFL BIOE TALKS SERIES\n\n--> PLEASE MIND THE UNUSUAL WEEKDAY and 
 TIME FOR THIS SEMINAR\, namely TUESDAY\, 14:15 (not Monday\, 12:15)!\nA fl
 ight cancellation made us reschedule the talk as the speaker could not mak
 e it to Lausanne before Tuesday.\nWe apologize for any inconvenience and t
 hank you for your understanding.\n\nAbstract:\nWe develop sequence-based a
 lgorithms to design functional proteins\, from CRISPR enzymes for precise 
 genome editing to transcription factors that direct differentiation of ova
 rian cells for fertility applications. The primary focus of this talk will
  be on our new language models (PepPrCLIP and PepMLM) that design de novo 
 peptides capable of binding and modulating undruggable\, disordered diseas
 e targets\, such as oncogenic fusion proteins and neurodegenerative protei
 n aggregates. To enhance design applications\, we will further introduce n
 ew models that extend the representation capacity of language models to po
 st-translational modifications (PTM-Mamba) and oncogenic fusion proteins (
 FusOn-pLM). Additionally\, we will highlight new frameworks for discrete g
 eneration of highly-specific\, therapeutic peptides that are simultaneousl
 y optimized for both target binding and drug-like properties (moPPIt and P
 epTune). Overall\, we believe that language models\, trained with biologic
 ally meaningful priors and augmented with application-aware sampling\, can
  unlock the next generation of therapeutics for currently intractable dise
 ases.\n\nBio:\nPranam Chatterjee is an Assistant Professor of Biomedical E
 ngineering and Computer Science at Duke University. His Programmable Biolo
 gy Group develops generative algorithms for de novo protein and peptide de
 sign\, integrating the newest advances in language modeling with translati
 onal in vitro and in vivo experimental platforms. Specifically\, the lab u
 ses these tools for diverse protein modulation\, genome editing\, and cell
  engineering applications. Having received his SB\, SM\, and PhD from MIT\
 , Professor Chatterjee has received the Hartwell Individual Biomedical Res
 earch Award and multiple NIH and foundation grants for his work. He has al
 so co-founded Gameto\, Inc. and UbiquiTx\, Inc. which translates his resea
 rch into fertility-related solutions and cancer therapeutics\, respectivel
 y.\n\n\n\nZoom link (with one-time registration for the whole series) for 
 attending remotely: https://go.epfl.ch/EPFLBioETalks\n\n\nInstructions for
  1st-year Ph.D. students planning to attend this talk\, who are under EDBB
 ’s mandatory seminar attendance rule:\nIN CASE you cannot attend in-pers
 on in the room\, please make sure to\n\n	send D. Reinhard a note well ahea
 d of time (ideally before seminar day)\, informing that you plan to attend
  the talk online\, and\, during seminar:\n	be signed in on Zoom with a rec
 ognizable user name (not any alias making it difficult or impossible to id
 entify you).\n\nStudents attending the seminar in-person should collect a 
 confirmation signature after the talk - please print your own signature sh
 eet beforehand (69 kB pdf available for download here). IMPORTANTLY: hang 
 on to this sheet as no signature record is being kept by anyone else!
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://go.epfl.ch/
 EPFLBioETalks
STATUS:CONFIRMED
END:VEVENT
END:VCALENDAR