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SUMMARY:IMX Talks - Reverse Engineering the Nervous System with Biohybrid 
 Electronics
DTSTART:20250908T141500
DTEND:20250908T145500
DTSTAMP:20260921T194853Z
UID:bc0ab15d9d956021e4f910906daa9b83d0dca40d9ead4b80936ee0a7
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Achilleas Savva\, Delft University of Technology\, The N
 etherlands.\nNeurodegenerative diseases represent more than 600 types of n
 ervous system disorders\, and are defined by increasing loss of structure 
 and function of neurons. In vitro cell cultures have played a significant 
 role in advancing the understanding of neurodegenerative diseases and faci
 litating research into regenerative pathways. Bioelectronic\, cell culture
  platforms allow for integration of bioelectronic cues to monitor or stimu
 late neuron regeneration\, in a controlled environment. Organic electronic
  materials\, notably conducting polymers\, enable 3D bioelectronic interfa
 ces and bridge the dimensionality mismatch between 2D/static electronics a
 nd 3D/dynamic biology. In this talk\, I will discuss the development of bi
 omimetic\, electrically active platforms for creating 3D neural networks i
 n vitro. First\, I will show the design of electrically conductive 3D scaf
 folds that support biomimetic human stem cell cultures. These scaffolds\, 
 made from porous poly(3\,4-ethylenedioxythiophene)(styrenesulfonate)\, (PE
 DOT:PSS)\, are integrated into electrode configurations and serve as platf
 orms for the growth of 3D human adipose-derived stem cells (hADSCs)\, faci
 litating their differentiation into neuron-like cells.[1]  Next\, I will 
 present the development of advanced 3D multifunctional porous scaffolds th
 at combine both electrical conductivity and photosensitivity. These scaffo
 lds are created by freeze-drying water-based solutions of PEDOT:PSS and th
 e semiconducting polymer P3CPT\, forming structures that enhance neural ce
 ll interaction. I will then describe the use of electrically conducting hy
 drogels in constructing 3D neural networks from human induced pluripotent 
 stem cells (iPSCs). Finally\, I will explain how we integrate these 3D con
 structs with microfabricated electrode arrays[3] to monitor biological sig
 nals\, capturing stem cell differentiation and neural activity.\n\nReferen
 ces:\n[1] 3D organic bioelectronics for electrical monitoring of human adu
 lt stem cells\, A. Savva\,* J. Saez\, A. Withers\, V. Stoeger\, C. Barberi
 o\, S. Elias-Kirma\, Z. Lu\, C.-M. Moysidou\, K. Kallitsis\, C. Pitsalidis
 \, R.M. Owens\, Materials Horizons\, 2023\, 10\, 3589-3600.\n[2] Electrica
 lly active\, Viscoelastic Hydrogels for 3D Neural Cultures\, L. Wang\, Y. 
 Hajee\, J.P. Frimat\, M. Diba\, A. Savva*\, In preparation.\n[3] Transpare
 nt Microelectrode Arrays for Neural Recordings. M. Shah\, J.P. Frimat\, A.
  Savva*\, In preparation. \n\n 
LOCATION:MXF 312 https://plan.epfl.ch/?room==MXF%20312
STATUS:CONFIRMED
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