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SUMMARY:IMX Talks - Micro electro-mechanical physiological systems (MEMPhy
 S)
DTSTART:20250908T150000
DTEND:20250908T154500
DTSTAMP:20260921T204436Z
UID:9f75708a3c9a837a024045a53e7d50bd7e04ad910bcec9ac24631654
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Massimo Mastrangeli\, Delft University of Technology\, T
 he Netherlands\nMicrophysiological systems (MPS) aim to recapitulate in vi
 tro relevant (patho)physiology and functionality of tissues and (parts of)
  organs [1]. For this purpose\, MPS need to accommodate 3D cell constructs
  and provide a comprehensive microenvironment that promotes cells’ targe
 t phenotype and functionality [2]. The microenvironment must include reali
 stic cues\, such as mechanical stress\, chemical gradients and electrical 
 stimulation among others. Moreover\, monitoring continuously the compositi
 on of the microenvironment and the health of the tissues is central to the
  assessment of the relevance and reproducibility of the model [3]. Continu
 ous monitoring entails the integration of sensors within MPS which quantif
 y important\, tissue-specific parameters such as e.g. flow rate of perfuse
 d fluid\, presence and concentration of analytes\, electrical impedance of
  tissues\, contractile kinetics\, electrogenic activity. Our research at T
 U Delft correspondingly aims to develop MPS capable of electro-mechanical 
 (EM) stimulation and sensing of cell constructs and tissues\, thereby prop
 erly turning MPS into actual MEMPhyS and hence into a subset of bioelectro
 nic devices dual to implantables.\nIn this presentation I will summarize t
 he rationale behind MEMPhyS\, and exemplify the potential of the electro-m
 echanical approach to MPS with several examples from our works\, including
  a technology platform for engineered heart tissues [4]\, FET-based charge
  sensors [5]\, a microfluidic device with integrated electrodes for tissue
  barrier assessment across a microporous membrane [6]\, and 3D microelectr
 ode arrays [7]. I will conclude outlining the perspectives opened by our w
 ork and its embedding within current projects and international standardiz
 ation initiatives fostering wider adoption of MPS technology.\n\nReference
 s\n[1]. M. Mastrangeli et al.\, ALTEX\, 36(4)\, 650-668\, 2019.\n[2]. D.M.
  Nahon et al.\, Nature Biomedical Engineering 8\, 941-962\, 2024.\n[3]. P.
  Tawade and M. Mastrangeli\, ChemBioChem 25(3)\, e202300560\, 2024\n[4]. M
 . Dostanic et al.\, IEEE Journal of Microelectromechanical Systems 29(5)\,
  881-887\, 2020\n[5]. H. Aydogmus et al.\, Scientific Reports 13(1)\, 8062
 \, 2023\n[6]. P. Tawade et al.\, Proceedings of IEEE MEMS 2025\n[7]. D. Se
 ngupta et al.\,  Proceedings of TRANSDUCERS 2025\, forthcoming\n\n 
LOCATION:MXF 312 https://plan.epfl.ch/?room==MXF%20312
STATUS:CONFIRMED
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