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VERSION:2.0
PRODID:-//Memento EPFL//
BEGIN:VEVENT
SUMMARY:Inaugural Lecture | Sara Gallini | Uncovering tumor suppression me
 chanisms through in vivo two-photon imaging
DTSTART:20250916T171500
DTEND:20250916T190000
DTSTAMP:20260415T185357Z
UID:d54307128c8d818c7202f8d612c2147789db87bad96f5c76e2b5bafa
CATEGORIES:Inaugural lectures - Honorary Lecture
DESCRIPTION:Sara Gallini\nUncovering tumor suppression mechanisms through 
 in vivo two-photon imaging\n\nProgram\n17:15 - 17:25  Welcome by Andy Oat
 es\, Dean SV and introduction by Elisa Oriccho\,  ISREC Director\n17:25 -
  18:00  Lecture by Sara Gallini: Uncovering tumor suppression mechanisms
  through in vivo two-photon imaging\n18:00 - 18:15  Q & A\n18:15 - 18:25
   Closure by Andy Oates\n18:25 - 19:00  Apéritif\n\nLocation: SV1717 an
 d retransmission to Campus Biotech (upon request)\nRegistration by Septemb
 er 9\, 2025\n\n\n\nAbstract\nTissues often harbor cancer-associated mutati
 ons\, yet tumors rarely form\, suggesting natural defense mechanisms limit
  oncogenic cell expansion. The skin epithelium\, a physiologically mosaic 
 tissue of healthy and mutant cells\, offers a powerful and accessible mode
 l to study these dynamics in real time. Cell competition\, in which fitter
  cells eliminate less fit neighbors\, maintains homeostasis but can be sub
 verted by oncogenic mutations. In Squamous Cell Carcinomas\, RAS\, one of 
 the most mutated oncogenes in human cancer\, increases mutant cell fitness
  and drives oncogenic growth. However\, this outcome is not inevitable. Bo
 th intrinsic and extrinsic mechanisms influence whether mutant cells are e
 liminated or persist.\nOur research combines in vivo two-photon imaging wi
 th molecular and spatial profiling to uncover how healthy cells suppress o
 ncogenic growth. By identifying key regulators\, we aim to enhance natural
  tumor suppression and develop new strategies for cancer prevention.\n\nBi
 o\nSara Gallini is a tenure-track Assistant Professor at EPFL’s School o
 f Life Sciences and the ISREC Institute. She earned her B.Sc. and M.Sc. in
  Biotechnology from the University of Bologna and completed her Ph.D. at t
 he European Institute of Oncology (IEO) in Milan\, revealing a novel role 
 for Aurora-A kinase and the junctional protein Afadin during cell division
 . As a postdoc in Valentina Greco’s lab at Yale University\, she leverag
 ed intravital imaging to study how wound repair influences tumor initiatio
 n. At EPFL\, her lab investigates how healthy and oncogenic cells interact
  in vivo to uncover mechanisms that preserve tissue homeostasis and preven
 t cancer.\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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