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SUMMARY:"Stereoselective Formation and Opening of Aromatic Rings"
DTSTART:20250925T171500
DTEND:20250925T180000
DTSTAMP:20260921T183914Z
UID:5cf197d8a362233a905bb317c3c225bbe424b763bd4aa3e8f00f8bc9
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Christof Sparr. University of Basel\nDue to the unfavora
 ble energetics in breaking aromaticity during ring opening\, catalytic\nar
 omatic ring cleavage remained largely unfeasible. In contrast\, alkene met
 athesis catalyzed\nby transition-metal alkylidenes is established as one o
 f the most versatile C=C bond forming\nand breaking reactions for non-arom
 atic structures. Despite remarkable advances\, strategies\nto open aromati
 c compounds by metathesis remain elusive. After highlighting methods for\n
 stereoselective arene formation\, this talk will discuss the cleavage of a
 romatic rings by\naromatic ring-opening metathesis (ArROM) by using Schroc
 k–Hoveyda molybdenum catalysts.\nWith different ring systems\, the react
 ions proceed through unique alkylidene intermediates.\nFurthermore\, the p
 ossibility for stereoselec0ve ArROM with exquisite catalyst control over t
 he\nconfiguration of atropisomers will be presented. Overall\, these metho
 ds will highlight that\nArROM is a viable and efficient approach to cataly
 tically transform and interconvert various\naromatics without the requirem
 ent for any reagents or photoexcitation.\nNature 2025\, 638\, 697–703.\n
  
LOCATION:Unil-salle Génopode B
STATUS:CONFIRMED
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