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VERSION:2.0
PRODID:-//Memento EPFL//
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SUMMARY:EPFL BioE Talks SERIES  "Nature’s Switches\, Our Tools: Environm
 entally-Controlled Protein/Protein Interactions"
DTSTART:20250924T104500
DTEND:20250924T114500
DTSTAMP:20260916T085034Z
UID:8d8950d5d79d4bf3a79588c44e535b1897be2b7bc3f0d8f640233c19
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Kevin Gardner\, City College of New York\, NYC\, NY (USA
 )\nWEEKLY EPFL BIOE TALKS SERIES\n\n>>> MIND THE UNUSUAL WEEKDAY (Wed) 
 AND TIME (10:45\, meaning no sandwiches this time...) <<<\n\nAbstract:\
 nEnvironmental cues regulate many cellular pathways in response to changin
 g conditions.  Such regulation is often initiated by sensory protein doma
 ins which expand their chemical repertoire by using small molecule ligands
  to convert environmentally-triggered changes into altered protein/protein
  interactions.  Combining biophysics\, biochemistry and synthetic chemist
 ry\, we study the mechanistic controls of such domains to understand funda
 mentals of biological signaling and how this might be altered in disease o
 r artificially controlled for therapeutic or biotech purposes.  Here I wi
 ll discuss several examples of this principle\, showing how our work into 
 light- and oxygen-regulated signaling proteins has led to novel optogeneti
 c tools and a first in-class anti-cancer therapeutic (Merck’s belzutifan
  HIF-2 inhibitor).  Future directions stemming from this work will also b
 e discussed.​​​​​​​\n\nBio:\nProf. Kevin Gardner is Director
  of the City University of New York (CUNY) Advanced Science Research Cente
 r's Structural Biology Initiative and Einstein Professor in the Departmen
 ts of Chemistry & Biochemistry\, at City College of New York.\nFollowing P
 h.D. studies at Yale and a postdoc at the University of Toronto\, Kevin Ga
 rdner established his independent lab at UT Southwestern Medical Center in
  1998.  In 2013\, he moved to New York to found and direct the Structural
  Biology Initiative of the new interdisciplinary CUNY Advanced Science Res
 earch Center and serve as the Einstein Professor of Chemistry & Biochemist
 ry at the City College of New York.  His studies have led not only to bet
 ter understanding of fundamental biology in several areas\, but also estab
 lished novel routes to artificially control protein activity.  Practical 
 applications of this through two companies spun out of his group\, Peloton
  Therapeutics\, Inc. and Optologix\, Inc.\, which have led to new targeted
  cancer therapies and optogenetic tools used in academic and industrial se
 ttings.\n\nZoom link (with one-time registration for the whole series) for
  attending remotely: https://go.epfl.ch/EPFLBioETalks\n\n\nInstructions fo
 r 1st-year Ph.D. students planning to attend this talk\, who are under EDB
 B’s mandatory seminar attendance rule:\nIN CASE you cannot attend in-per
 son in the room\, please make sure to\n\n	send D. Reinhard a note well ahe
 ad of time (ideally before seminar day)\, informing that you plan to atten
 d the talk online\, and\, during seminar:\n	be signed in on Zoom with a re
 cognizable user name (not any alias making it difficult or impossible to i
 dentify you).\n\nStudents attending the seminar in-person should collect a
  confirmation signature after the talk - please print your own signature s
 heet beforehand (69 kB pdf available for download here). IMPORTANTLY: hang
  on to this sheet as no signature record is being kept by anyone else!
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://go.epfl.ch/
 EPFLBioETalks
STATUS:CONFIRMED
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