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VERSION:2.0
PRODID:-//Memento EPFL//
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SUMMARY:EPFL BioE Talks SERIES  "Studying Developmental Perturbations With
  Mouse Embryo-Like Structures"
DTSTART:20250915T121500
DTEND:20250915T131500
DTSTAMP:20260405T192139Z
UID:e2ea97c6b409e91fe607023fb1a194f3eb7ee9e58dfb2d2bbedd796b
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Gianluca Amadei\, Department of Biology\, University of 
 Padova (IT)\nWEEKLY EPFL BIOE TALKS SERIES (sandwiches provided)\n\nAbstr
 act:\nUnderstanding how signaling pathways regulate the development of mam
 malian embryos is a very important\, yet difficult\, task. In fact\, most 
 of embryonic development is hidden in the maternal uterus and embryos do n
 ot readily lend themselves to ex utero culture and manipulations. Stem cel
 l models\, on the other hand\, possess several features (modularity\, scal
 ability\, amenability to genetic manipulation) that enable us to explore d
 evelopment in ways that are not readily achievable with natural embryos\, 
 either mouse or human. My current research is centred on the stem cell-bas
 ed\, embryo-like model system called ETiX-embryoids. These structures form
  by combining Embryonic stem cells (ES cells)\, Trophoblast stem cells (TS
  cells) and induced eXtraembryonic endoderm stem cells. Unlike other stem 
 cell or organoid models\, ETiX-embryoids develop in culture like post-impl
 antation mouse embryos and over the course of eight days they undertake ne
 urulation and organogenesis\, forming a patterned neural tube\, a brain\, 
 a beating heart-like structure\, gut tube and tail. Furthermore\, these st
 ructures develop inside yolk sac and amnion membranes\, like natural mouse
  embryos\, thus enabling in vitro modelling of embryonic and extraembryoni
 c tissue crosstalk. Here\, I show how ETiX-embryoids can be utilised as a 
 proxy to model and study early mouse embryo post-implantation development 
 by shedding light on an early role for TGF-β signalling.\n\nBio:\nGianluc
 a Amadei has completed his PhD at the University of Toronto under the supe
 rvision of Dr. Freda Miller studying how RNA-binding proteins regulate the
  development of the early mouse embryonic brain. He then moved to the Univ
 ersity of Cambridge in the UK where\, as a postdoctoral fellow under the s
 upervision of Prof. Magdalena Zernicka-Goetz\, he developed stem cell-base
 d models of mouse early post-implantation development. Dr. Amadei is now a
 n Assistant Professor in the Department of Biology at the University of Pa
 dova\, Italy\, where he is using these models as a proxy of mouse embryos 
 to understand how development unfolds under normal and abnormal conditions
 .\n\n\nZoom link (with one-time registration for the whole series) for att
 ending remotely: https://go.epfl.ch/EPFLBioETalks\n\n\nInstructions for 1s
 t-year Ph.D. students planning to attend this talk\, who are under EDBB’
 s mandatory seminar attendance rule:\nIN CASE you cannot attend in-person 
 in the room\, please make sure to\n\n	send D. Reinhard a note well ahead o
 f time (ideally before seminar day)\, informing that you plan to attend th
 e talk online\, and\, during seminar:\n	be signed in on Zoom with a recogn
 izable user name (not any alias making it difficult or impossible to ident
 ify you).\n\nStudents attending the seminar in-person should collect a con
 firmation signature after the talk - please print your own signature sheet
  beforehand (69 kB pdf available for download here). IMPORTANTLY: hang on 
 to this sheet as no signature record is being kept by anyone else!
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://go.epfl.ch/
 EPFLBioETalks
STATUS:CONFIRMED
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