BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Memento EPFL//
BEGIN:VEVENT
SUMMARY:Biophysical Principles of Genome Organization Across Multiple Scal
 es
DTSTART:20250929T121500
DTEND:20250929T131500
DTSTAMP:20260506T165919Z
UID:131f8b74a9ec4a3adc74298c7b2027d4af4bb84f2a20b650a191d322
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Taekjip Ha\,  Howard Hughes Medical Institute & Progra
 m in Cellular and Molecular Medicine\, Boston Children's Hospital / Depart
 ment of Biological Chemistry and Molecular Pharmacology\, Harvard Medical 
 School\nRecent advances in genetics\, biochemistry\, cell biology\, and bi
 ophysics have contributed to our understanding that the genome is organize
 d hierarchically\, with higher-order macromolecular assemblies spanning sp
 atial and temporal orders of magnitude. Beyond being wrapped around histon
 es as irregular groups of “beads on a string”\, chromatin is organized
  into topologically associated domains\, which are composed of small and l
 arge loops\, and form euchromatic and heterochromatic compartments. In thi
 s talk\, I will present biophysical principles we are uncovering about gen
 ome organization across three different scales\, including sequence-depend
 ent DNA mechanics\, chromatin loops for homology search\, and polyamines' 
 role in translating nucleosome condensability into 3D genome organization.
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
END:VEVENT
END:VCALENDAR