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SUMMARY:EPFL BioE Talks SERIES  "Charting Cellular Responses to Genotoxic 
 Stress by Multidimensional Imaging"
DTSTART:20260223T121500
DTEND:20260223T131500
DTSTAMP:20260405T205228Z
UID:2a4248cdb24f7d3d9099251a8dd5f79d4aca60607398b12ce8cc6c67
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Matthias Altmeyer\, Department of Molecular Mechanisms o
 f Disease\, University of Zurich (CH)\nWEEKLY EPFL BIOE TALKS SERIES (sand
 wiches provided)\n\nAbstract:\nCellular heterogeneity is pervasive in natu
 re yet insufficiently represented in ensemble behaviors of cell population
 s. Although biological processes affected by cell-to-cell variation are ma
 nifold\, from developmental plasticity to tumor heterogeneity and differen
 tial drug responses\, its sources remain largely unknown. Mutational and e
 pigenetic signatures from cancer genomics are powerful to deduce processes
  that shaped cancer genome evolution. However\, it is difficult to infer f
 rom retrospective analyses how phenotypic plasticity emerges and how it is
  propagated to subsequent cell generations. We are pursuing multidimension
 al cell imaging approaches to elucidate how genotoxic stresses such as DNA
  damage from ionizing radiation\, activation of targeted endonucleases\, o
 ncogene-induced replication stress\, and genotoxic stress induced by inhib
 itors of DNA damage and replication stress responses\, affect genome maint
 enance at the single cell level and cellular heterogeneity at the cell pop
 ulation level. These include cell cycle-resolved high-throughput microscop
 y and\, more recently\, \nmultigenerational single cell tracking based on
  endogenously labeled markers of DNA replication and heritable DNA lesions
 . Besides analyzing replication and repair dynamics\, damage inheritance\,
  and emergence of sister cell heterogeneity across multiple cell generatio
 ns\, by combining multigenerational live cell imaging with targeted end-po
 int measures\, we study how common oncogenic events trigger multiple route
 s towards polyploidization with distinct outcomes for genome integrity.\n\
 nBio:\nProf. Matthias Altmeyer studied Biology with a focus on Molecular a
 nd Cell Biology at the University of Konstanz\, Germany. He earned his doc
 toral degree from the University of Zurich\, Switzerland\, through the Mol
 ecular Life Sciences PhD Program of the Life Science Zurich Graduate Schoo
 l\, where he explored genome biology and PTM-regulated stress signaling. D
 uring his postdoctoral research in Copenhagen\, Denmark\, first at the Gen
 ome Integrity Unit of the Danish Cancer Society and later at the Novo Nord
 isk Foundation Center for Protein Research at the University of Copenhagen
 \, he investigated mechanisms of genome maintenance\, supported by fellows
 hips from EMBO and the Danish Research Council\, as well as a Sapere Aude 
 research talent grant. In 2014\, he returned to the University of Zurich t
 o establish his independent research group at the Department of Molecular 
 Mechanisms of Disease\, supported by an SNSF Professorship and an ERC Star
 ting Grant. His current work centers on the spatial organization\, dynamic
 s\, and cell cycle control of replication stress and DNA damage responses.
 \n\n\nZoom link (with one-time registration for the whole series) for atte
 nding remotely: https://go.epfl.ch/EPFLBioETalks\n\n\nInstructions for 1st
 -year Ph.D. students planning to attend this talk\, who are under EDBB’s
  mandatory seminar attendance rule:\nIN CASE you cannot attend in-person i
 n the room\, please make sure to\n\n	send D. Reinhard a note well ahead of
  time (ideally before seminar day)\, informing that you plan to attend the
  talk online\, and\, during seminar:\n	be signed in on Zoom with a recogni
 zable user name (not any alias making it difficult or impossible to identi
 fy you).\n\nStudents attending the seminar in-person should collect a conf
 irmation signature after the talk - please print your own signature sheet 
 beforehand (69 kB pdf available for download here). IMPORTANTLY: hang on t
 o this sheet as no signature record is being kept by anyone else!
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://go.epfl.ch/
 EPFLBioETalks
STATUS:CONFIRMED
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