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SUMMARY:EPFL BioE Talks SERIES  "Biophysical Principles of Genome Organiza
 tion Across Multiple Scales"
DTSTART:20250929T121500
DTEND:20250929T131500
DTSTAMP:20260502T032339Z
UID:5a8c64630bb18bd736f1a91243572510741ef08023d9f67d7cf5a3e3
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Taekjip Ha\, Boston Children's Hospital\, Harvard Medic
 al Medical School\, Boston\, MA (USA)\nWEEKLY EPFL BIOE TALKS SERIES join
 tly with Physics Colloquia Series\n(sandwiches provided)\n\nAbstract:\nRec
 ent advances in genetics\, biochemistry\, cell biology\, and biophysics ha
 ve contributed to our understanding that the genome is organized hierarchi
 cally\, with higher-order macromolecular assemblies spanning spatial and t
 emporal orders of magnitude. Beyond being wrapped around histones as irreg
 ular groups of “beads on a string”\, chromatin is organized into topol
 ogically associated domains\, which are composed of small and large loops\
 , and form euchromatic and heterochromatic compartments. In this talk\, I 
 will present biophysical principles we are uncovering about genome organiz
 ation across three different scales\, including sequence-dependent DNA mec
 hanics [1]\, chromatin loops for homology search [2]\, and polyamines' rol
 e in translating nucleosome condensability into 3D genome organization [3]
 .\n \n[1] doi: 10.1101/2024.12.22.629997\n[2] doi: 10.1101/2025.02.10.637
 451\n[3] doi: 10.1038/s41586-025-08971-7\n\n\nBio:\n\nEDUCATION & TRAINING
 \n1990           B.S. in Physics\, Seoul National University\, S
 eoul\, Republic of Korea\n1996           Ph.D. in Physics\, Universi
 ty of California at Berkeley\, Berkeley\, CA\n              
      Thesis: Fluorescence Spectroscopy of Single Molecules at Room Tem
 perature and Its Applications\n                   (advis
 ors: Shimon Weiss and Daniel Chemla)\n1997           Postdoctora
 l Fellow (advisors: Shimon Weiss and Daniel Chemla)\, Materials Sciences D
 ivision\, Lawrence Berkeley National Laboratory\, Berkeley\, CA\n1998-2000
     Postdoctoral Fellow (advisor: Steven Chu)\, Physics Dept\, Stanfor
 d Univ\, Stanford\, CA\n\nPOST TRAINING POSITIONS\n08/2023-present:   
      George D. Yancopoulos in Honor of Frederick W. Alt Professor of P
 ediatrics\,\n                                  
  Faculty affiliate\, Department of Biological Chemistry and Molecular Pha
 rmacology\, Harvard Medical School\;\n                    
                Senior Investigator of Program in Cellular and M
 olecular Medicine\, Boston Children’s Hospital\n01/2025-present:    
     Director\, Program in Cellular and Molecular Medicine\, Boston Chil
 dren’s Hospital\n08/2015-07/2023:       Bloomberg Distinguished Pr
 ofessor of Biophysics & Biophysical Chemistry\, Biophysics and Biomed. Eng
 .\, Johns Hopkins University\n09/2005–present:       Investigator\
 , Howard Hughes Medical Institute\n01/2012–08/2015:      Edward Wil
 liam and Jane Marr Gutgsell Endowed Professor\, University of Illinois at 
 Urbana-Champaign\n08/2010–08/2015:      Theme Leader “Cellular De
 cision Making in Cancer\,” Institute for Genomic Biology\, University of
  Illinois\n09/2008–08/2015:      Co-director\, Center for the Physi
 cs of Living Cells\, University of Illinois\n08/2007–08/2015:      
 Professor\, Department of Physics and Center for Biophysics and Computatio
 nal Biology\, University of Illinois\n07/2013-12/2014:       Director\
 , Center for Biophysics and Quantitative Biology\, University of Illinois\
 n08/2004–08/2007:      Associate Professor\, Department of Physics 
 and Center for Biophysics and Computational Biology\, University of Illino
 is\n08/2000–07/2004:      Assistant Professor\, Department of Physi
 cs and Center for Biophysics and Computational Biology\, University of Ill
 inois\n\n\n\nZoom link (with one-time registration for the whole series) f
 or attending remotely: https://go.epfl.ch/EPFLBioETalks\n\n\nInstructions 
 for 1st-year Ph.D. students planning to attend this talk\, who are under E
 DBB’s mandatory seminar attendance rule:\nIN CASE you cannot attend in-p
 erson in the room\, please make sure to\n\n	send D. Reinhard a note well a
 head of time (ideally before seminar day)\, informing that you plan to att
 end the talk online\, and\, during seminar:\n	be signed in on Zoom with a 
 recognizable user name (not any alias making it difficult or impossible to
  identify you).\n\nStudents attending the seminar in-person should collect
  a confirmation signature after the talk - please print your own signature
  sheet beforehand (69 kB pdf available for download here). IMPORTANTLY: ha
 ng on to this sheet as no signature record is being kept by anyone else!
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://go.epfl.ch/
 EPFLBioETalks
STATUS:CONFIRMED
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