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SUMMARY:EPFL BioE Talks SERIES  "The Role of Deleterious Mutations in Stru
 ctured Populations"
DTSTART:20251006T121500
DTEND:20251006T131500
DTSTAMP:20260428T030709Z
UID:d89297d5021fc8b45cded2a222509a96a465713cd60730b36c479ae5
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Joachim Krug\, Institute for Biological Physics\, Unive
 rsity of Cologne (D)\nWEEKLY EPFL BIOE TALKS SERIES (sandwiches provided)\
 n\nAbstract:\nPopulation genetic theory for well-mixed populations posits 
 that deleterious mutations have no appreciable role in the adaptation of l
 arge populations\, because they are efficiently purged by natural selectio
 n. In this talk I will argue that this intuition is generally misguided wh
 en dealing with structured populations. I will present results of three ca
 se studies on spatial and graph-structured populations that exemplify the 
 unusual evolutionary dynamics that can occur in these systems. Specificall
 y\, I will show that rare beneficial mutations cannot halt Muller's ratche
 t in spatial populations\, and that strongly inhomogeneous graph structure
 s may revert the direction of natural selection under mutation-selection b
 alance\, leading to the phenomenon of "survival of the weakest".\n\nThe ta
 lk is based on joint work with Su-Chan Park\, Nikhil Sharma\, Suman Das an
 d Arne Traulsen.\n\n\nBio:\nJoachim Krug studied physics in Göttingen and
  Munich\, and received a doctoral degree in theoretical physics from the L
 MU Munich in 1989. After postdoctoral appointments at the IBM Thomas J. Wa
 tson Research Center in Yorktown Heights (NY) and Forschungszentrum Jülic
 h\, he became a professor of theoretical physics at the University of Esse
 n in 1996. In 2004\, he joined the University of Cologne\, where he co-fou
 nded the Institute for Biological Physics in 2018. He has held visiting po
 sitions at the Danish Technical University\, the Helsinki University of Te
 chnology\, the Hebrew University of Jerusalem\, the University of Florence
  and the University of Edinburgh. Krug has authored more than 200 publicat
 ions covering a broad range of topics in statistical physics\, theoretical
  population genetics and evolutionary biology. He is a PI within the Colla
 borative Research Center "Predictability in Evolution". His current resear
 ch interests include the causes and consequences of epistatic interactions
 \, models of fitness landscapes\, and the evolution of antimicrobial resis
 tance.\n\n\nZoom link (with one-time registration for the whole series) fo
 r attending remotely: https://go.epfl.ch/EPFLBioETalks\n\n\nInstructions f
 or 1st-year Ph.D. students planning to attend this talk\, who are under ED
 BB’s mandatory seminar attendance rule:\nIN CASE you cannot attend in-pe
 rson in the room\, please make sure to\n\n	send D. Reinhard a note well ah
 ead of time (ideally before seminar day)\, informing that you plan to atte
 nd the talk online\, and\, during seminar:\n	be signed in on Zoom with a r
 ecognizable user name (not any alias making it difficult or impossible to 
 identify you).\n\nStudents attending the seminar in-person should collect 
 a confirmation signature after the talk - please print your own signature 
 sheet beforehand (69 kB pdf available for download here). IMPORTANTLY: han
 g on to this sheet as no signature record is being kept by anyone else!
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://go.epfl.ch/
 EPFLBioETalks
STATUS:CONFIRMED
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