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SUMMARY:Regulon Velocity-Based Single-Cell Dynamics for Interpretable Mode
 lling of CD8 T-Cell Fate Commitment
DTSTART:20260513T110000
DTEND:20260513T120000
DTSTAMP:20260508T032346Z
UID:154ab2f0e00c2b3d2e90c0c1c1646616b45c4f67d824770f1b836746
CATEGORIES:Conferences - Seminars
DESCRIPTION:Jesus Corria-Osorio\, Associate Director\, Responsible for Syn
 thetic T-cell Biology and Engineering\, UNIL\nAbstract:\n\nHow CD8 T cells
  commit to distinct differentiation states is a central question in immuno
 logy and an important challenge for cell engineering. In this seminar\, I 
 will present a framework under development that projects gene expression a
 nd RNA velocity into an interpretable regulon activity space\, enabling co
 ntinuous dynamical modeling over transcription factor regulatory programs 
 rather than gene-expression coordinates alone. Using chronic LCMV-specific
  CD8 T cells as a model system\, I will show how this approach supports th
 e reconstruction of continuous vector fields\, the identification of fixed
  points\, and the characterization of saddle-local neighborhoods that are 
 especially informative for fate commitment. I will focus in particular on 
 a saddle-like neighborhood along the Tpex–Texint differentiation axis\, 
 where local dynamical analysis reveals branch-defining unstable modes and 
 opposing transcription factor modules associated with commitment bias. Mor
 e broadly\, this work illustrates how differentiable regulon-space dynamic
 s can connect single-cell state transitions to mechanistic regulatory inte
 rpretation\, with potential applications in regulator prioritization\, rep
 rogramming prediction\, and CD8 T-cell engineering for cancer immunotherap
 y.\n \n\nBiography:\nJesus Corria-Osorio is a physician-scientist and Pr
 incipal Investigator in Synthetic T-cell Biology and Engineering at the Co
 ukos Lab\, University of Lausanne. His research combines single-cell genom
 ics\, in vivo CRISPR screening\, and mathematical modeling to understand a
 nd engineer non-canonical CD8+ T-cell states for cancer immunotherapy. Aft
 er initial training in clinical immunology in Cuba\, he completed his doct
 oral studies in the Cancer and Immunology program at the University of Lau
 sanne under the supervision of Professor George Coukos. He has recently be
 en appointed Assistant Professor of Immunology in Medicine at Weill Cornel
 l Medicine\, where he will work alongside Professor George Coukos to devel
 op next-generation T-cell therapies inspired by AI-driven discovery\, syst
 ems biology\, and synthetic biology\, and to advance them into early-phase
  clinical testing across multiple tumor types.
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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