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SUMMARY:Spatial Sequencing of Host-Microbiome Interactions
DTSTART:20251104T121500
DTEND:20251104T131500
DTSTAMP:20260501T165523Z
UID:c407c2f36c66440d614c5cf1693a349e8639444912279496e33e5239
CATEGORIES:Conferences - Seminars
DESCRIPTION:Iwijn de Vlaminck\, Cornell University\, USA\nMicrobe-microbe 
 and host–microbe interactions are central to the functioning of the huma
 n microbiome\, but few tools are available to measure these interactions s
 patially within tissues. In this talk\, Dr. De Vlamink introduced multiple
 xed imaging and spatial RNA sequencing approaches that enable simultaneous
  mapping of gut microbial communities\, host gene expression and host gene
  regulation at single-micron resolution. By applying these methods\, he re
 vealed the longitudinal stability of spatial architectures in the healthy 
 human oral plaque microbiome\, demonstrated the location-dependent organiz
 ation of microbial communities in the mouse intestine\, and revealed inter
 actions within and between microbial taxa at short length scales. Dr. De V
 lamink also showed how these tools reveal changes in microbial and host ce
 ll architectures at microbiome–tumor interfaces. Last\, he discussed rec
 ent extensions of these methods to enable spatial mapping of mobile geneti
 c elements and their bacterial hosts in complex microbiomes. Together\, th
 ese methods provide a new avenue to study host-microbiome interactions\, w
 ith the potential for significant advances in microbiome science.
LOCATION:SV 1717 https://plan.epfl.ch/?room==AI%201153
STATUS:CONFIRMED
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