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SUMMARY:MechE Colloquium: Mechanically-driven closure of extreme membrane 
 wounds in a single cell
DTSTART:20260324T120000
DTEND:20260324T130000
DTSTAMP:20260430T175503Z
UID:37cb35505bab854edb8f71f1200e2eb95299872074eeb433f4cddaf7
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Sindy KY Tang\, Dept. of Mechanical Engineering\, Stan
 ford University\nAbstract: Wound healing is a fundamental aspect of livin
 g systems and is increasingly recognized in single cells. However\, our un
 derstanding of single-cell wound healing is limited as many cell types use
 d in prior studies cannot survive wounds larger than a few percent of the 
 cell membrane area. In contrast\, the giant single-celled ciliate Stentor 
 coeruleus is a unique model that can robustly heal and regenerate from dra
 stic wounds. Here\, we leverage microfluidics to study the interplay of wo
 und healing capacity\, wound size\, and cell size in Stentor. Remarkably\,
  at all cell sizes tested\, Stentor easily survives wounds up to 60% of th
 e cell membrane area\, larger than any wounds reported in other single-cel
 l models. This critical wound size corresponds to the geometric limit wher
 e the intact membrane area equals the minimum area needed to cover the cel
 l volume (i.e.\, that of a sphere). In contrast to prior studies that only
  reported local wound healing events\, we observe large-scale wrapping of 
 intact cell membrane to aid in wound closure. We then show membrane wrappi
 ng is driven by KM fiber extension. Our work highlights how single cells c
 an act as mechanical systems to enable large-scale cell functions. Finally
 \, we will briefly discuss extension of our microfluidic tools to dissect 
 tissues for applications in organoid generation and spatial biology.\n\nBi
 ography: Prof. Sindy KY Tang is the Kenneth and Barbara Oshman Faculty Sc
 holar and Associate Professor of Mechanical Engineering and by courtesy of
  Bioengineering and Radiology (Precision Health and Integrated Diagnostics
 ) at Stanford University. She received her Ph.D. from Harvard University i
 n Engineering Sciences. The micro-nano-bio lab under the direction of Prof
 . Tang aims to develop innovative micro and nanoscale devices that enable 
 precise manipulation\, measurement\, and recapitulation of biological syst
 ems\, in order to understand the "rules of life" and accelerate precision 
 medicine and material design for a future with better health and environme
 ntal sustainability. Prof. Tang’s work has been recognized by multiple a
 wards including the NSF CAREER Award\, and invited lecture at the Nobel Sy
 mposium on Microfluidics in Sweden.
LOCATION:MED 0 1418 https://plan.epfl.ch/?room==MED%200%201418 https://epf
 l.zoom.us/j/61360740951
STATUS:CONFIRMED
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