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SUMMARY:Mechanical characterization of soft human tissue for applications 
 in medicine
DTSTART:20121211T141500
DTEND:20121211T151500
DTSTAMP:20260406T121536Z
UID:772d8263a3370d7535514a5ad2dabe269617d5047991d019e106b587
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Edoardo Mazza\, ETHZ\, Switzerland\nTwo aspects will be 
 considered in the talk: (i) characterization of biological membranes subje
 cted to uniaxial and biaxial stress states\, (ii) in vivo measurement of t
 he mechanical response of soft human organs using the aspiration method.\n
 \n(i) We investigate the multi-axial mechanical response of biological mem
 branes\, such as fetal membranes (amnio-chorion) and Glisson’s capsule. 
 The predictive capabilities of hyperelastic viscoelastic constitutive mode
 l formulations are evaluated with respect to the experimental results obta
 ined in different loading conditions. Unexpected features are observed\, s
 uch as large lateral contractions (leading to in-plane area reduction!) in
  uniaxial tension\, and biaxial stiffness by an order of magnitude larger 
 compared to the uniaxial case. Semi-quantitative assessment of elastin and
  total collagen content in the membranes allows evaluating correlations be
 tween mechanical parameters and tissue microstructure. Implications of the
  observed deformation behavior on the clinical problem of premature ruptur
 e of fetal membranes are discussed.\n\n(ii) Results will be presented from
  clinical studies with aspiration experiments on the liver during open abd
 ominal surgery and intra-vaginal on the uterine cervix in the course of ge
 station. An extensive experimental campaign with measurements on patients 
 undergoing hepatic resection has been recently completed. Histopathologica
 l characterization with biopsies taken at the measurement location allows 
 analyzing the correlation between mechanical response and local tissue alt
 erations. The measurements performed on the uterine cervix of 50 pregnant 
 women at different gestational ages provide information on the correspondi
 ng changes in mechanical properties of the ectocervix. This procedure migh
 t form the basis for a new diagnostic method to complement morphological e
 valuations when predicting pre-term delivery.
LOCATION:ME B3 31 http://plan.epfl.ch/?room=MEB331
STATUS:CONFIRMED
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