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SUMMARY:Exciting Instruments Seminar : Adding Dynamics to Structural Biolo
 gy
DTSTART:20251127T140000
DTEND:20251127T153000
DTSTAMP:20261007T113421Z
UID:54a33785cc23e001f96f49266ef3e692eaf2d85bfc52f11bd3050a46
CATEGORIES:Conferences - Seminars
DESCRIPTION:Mahmoud Abdelhamid\, Roman Renger\, Timothy Craggs (Exciting I
 nstruments Ltd)\nAdding dynamics to structural biology - Easy-to-use singl
 e-molecule fluorescence tools to complement AI-powered protein design and 
 static structural models\n\nStructural biology methods like cryo-electron 
 microscopy and X-ray crystallography are enormously powerful tools to unra
 vel biomolecular mechanisms of action. More recently\, Artificial Intellig
 ence and other computational approaches have opened new frontiers in prote
 in design and structure determination. However\, due to the largely static
  nature of their outputs\, both types of approaches are typically unable t
 o provide insights into the dynamics of biomolecular complexes\, such as t
 emporal conformational changes\, binding kinetics and diffusion properties
 . Dynamic single-molecule techniques\, such as Förster Resonance Energy T
 ransfer (smFRET) and Fluorescence Correlation Spectroscopy (FCS) fill this
  gap. By revealing transient states and heterogeneous populations in real 
 time\, these approaches bridge the gap between high-resolution structures 
 and functional dynamics\, enabling a comprehensive understanding of biomol
 ecular mechanisms. Unfortunately\, so far\, these methods have been inacce
 ssible to the broader life science and drug development community.\n\nHere
 \, we introduce the EI-FLEX\, a novel benchtop instrument designed for sea
 mless smFRET and FCS measurements\, democratizing access to these powerful
  techniques. Its compact\, user-friendly design requires minimal setup and
  no specialized expertise\, allowing researchers in standard laboratory en
 vironments to perform experiments effortlessly\, at high throughput. Ease-
 of-use is achieved through integrated calibration and correction routines 
 and automated sample handling\, supporting rapid screening of multiwell pl
 ates as well as individual samples with sub-millisecond and sub-nm spatio-
 temporal resolution and single molecule sensitivity. Data analysis is stre
 amlined via intuitive software featuring automated fitting algorithms\, re
 al-time visualization\, and exportable reports\, minimizing post-processin
 g time and errors.\n\nThe EI-FLEX empowers structural biologists\, biochem
 ists and drug developers to finally incorporate dynamic data on the level 
 of individual biomolecular complexes into their workflows. It\nenables the
 m to truly unravel and quantify drug-target interactions\, complex formati
 on and biomolecular conformational changes at unprecedented spatio-tempora
 l resolution. By lowering barriers to entry\, it propels the field toward 
 faster\, more complete discoveries in complex biomolecular systems.
LOCATION:CH G1 495 https://plan.epfl.ch/?room==CH%20G1%20495
STATUS:CONFIRMED
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