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SUMMARY:EPFL BioE Talks SERIES  "Protein Quality Control of Stress Granule
 s: Implications in Amyotrophic Lateral Sclerosis"
DTSTART:20260112T121500
DTEND:20260112T131500
DTSTAMP:20260405T222503Z
UID:6553bd2616b1ebd77ee93b7281f4a1b8ff1985a71f9a9cc6c4728a81
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Serena Carra\, Department of Biomedical\, Metabolical an
 d Neurosciences\, University of Modena and Reggio Emilia (IT)\nWEEKLY EP
 FL BIOE TALKS SERIES (sandwiches provided)\n\nAbstract: \nWild-type TDP-4
 3 forms cytosolic inclusions in patients afflicted by Amyotrophic Lateral 
 Sclerosis (ALS).\nThe origin of TDP-43 aggregates and the mechanisms used 
 by cells to counteract TDP-43 aggregation are only partly understood.\nStr
 ess conditions trigger the accumulation of TDP-43 in stress granules (SGs)
 \, which are dynamic RNA-containing condensates. The role of SGs in modula
 ting TDP-43 aggregation is ambiguous. TDP-43 can misfold and aggregate ind
 ependently of SGs\, but chronic induction of SGs has been shown to trigger
  the formation of cytosolic TDP-43 inclusions that cause neurotoxicity.\nI
  will present data supporting the role of the protein quality control (PQC
 ) and stress-induced post-translational modifications in preventing protei
 n aggregation inside SGs. Potentiating the PQC of SGs could prevent TDP-43
  aggregation during stress.\n\n\nBio:\nSerena Carra received her PhD in Ne
 urobiology from the University of Catania (Italy) in 2004. After postdocto
 ral research with Prof. Landry (Laval University\, Canada)\, Prof. Kamping
 a (University Medical Centre Groningen - UMCG\, The Netherlands)\, she sta
 rted her independent career in 2009 at UMCG. During this period\, Serena d
 iscovered the HSPB8-BAG3-HSP70 chaperone complex and its role in targeting
  misfolded proteins to autophagy for clearance\, with implications for neu
 rodegenerative diseases. In 2011\, Serena received the Rita Levi Montalcin
 i Prize and moved to the University of Modena and Reggio Emilia\, Italy\, 
 where she is Associate Professor of Molecular Biology since 2015. Here\, s
 he studies how the protein quality control system prevents the aggregation
  of proteins and maintains the dynamic properties of biomolecular condensa
 tes such as stress granules\, and how failure thereof contributes to neuro
 degeneration and neuromuscular disorders.\n\n\nZoom link (with one-time re
 gistration for the whole series) for attending remotely: https://go.epfl.c
 h/EPFLBioETalks\n\n\nInstructions for 1st-year Ph.D. students planning to 
 attend this talk\, who are under EDBB’s mandatory seminar attendance rul
 e:\nIN CASE you cannot attend in-person in the room\, please make sure to\
 n\n	send D. Reinhard a note well ahead of time (ideally before seminar day
 )\, informing that you plan to attend the talk online\, and\, during semin
 ar:\n	be signed in on Zoom with a recognizable user name (not any alias ma
 king it difficult or impossible to identify you).\n\nStudents attending th
 e seminar in-person should collect a confirmation signature after the talk
  - please print your own signature sheet beforehand (69 kB pdf available f
 or download here). IMPORTANTLY: hang on to this sheet as no signature reco
 rd is being kept by anyone else!
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://go.epfl.ch/
 EPFLBioETalks
STATUS:CONFIRMED
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