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SUMMARY:“Mechanisms driving the rapid evolution of genomes”
DTSTART:20260604T121500
DTEND:20260604T131500
DTSTAMP:20260513T015904Z
UID:c5f68dbdfb28421f9a4452a01d69cb87fe5d944891cbb9f5f1f11b64
CATEGORIES:Conferences - Seminars
DESCRIPTION:David Pellman\, M.D.\, Margaret M. Dyson Professor of Pediatri
 c Oncology\, Dana-Farber Cancer Institute\, a Professor of Cell Biology at
  Harvard Medical School\, an Investigator of the Howard Hughes Medical Ins
 titute\, and the Associate Director for Basic Science at the Dana-Farber/H
 arvard Cancer Center. \nA Lola and John Grace Distinguished Lecture in Ca
 ncer Research\n\n\n\n\n\n\nDavid Pellman\, M.D. is the Margaret M. Dyson P
 rofessor of Pediatric Oncology at the Dana-Farber Cancer Institute\, a Pro
 fessor of Cell Biology at Harvard Medical School\, an Investigator of the 
 Howard Hughes Medical Institute\, and the Associate Director for Basic Sci
 ence at the Dana-Farber/Harvard Cancer Center.  He received his undergrad
 uate and medical degrees from the University of Chicago.  During medical 
 school\, he did research at the Rockefeller University.  His postdoctoral
  fellowship was at the Whitehead Institute/Massachusetts Institute of Tech
 nology.\n\nThe Pellman Lab works on the mechanism of cell division and how
  certain cell division errors drive rapid genome evolution.  His research
  has contributed to the understanding of cell division\, the origin of cel
 l division errors in cancer\, how cell division errors drive genetic insta
 bility and the mechanisms driving rapid evolution of cancer genomes. Our c
 ontributions include (1) the co-discovery of formin-dependent actin nuclea
 tion and a mechanism for spindle positioning during asymmetric cell divisi
 on\, (2) discoveries establishing that whole genome duplication can drive 
 tumorigenesis\, alter cell physiology\, and accelerate evolutionary adapta
 tion\, and (3) the discovery of a mechanism explaining chromothripsis\, a 
 mutational process that generates rapid karyotype evolution in cancer and 
 congenital disease.\n\n\n\n\n\n\n\n\n \n
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://epfl.zoom.u
 s/j/97039045251?pwd=WDFjUGV3Y1FxeG9rTUIrOGpiUXhLQT09
STATUS:CONFIRMED
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