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SUMMARY:EPFL BioE Talks SERIES  "Regulating DNA Repair in Space and Time"
DTSTART:20260209T121500
DTEND:20260209T131500
DTSTAMP:20260916T085033Z
UID:46de79b10095abe1053d83dbeeba5d932b8299e21aa86351875868bb
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Megan C. King\, Yale University\, New Haven\, CT (USA)\
 nWEEKLY EPFL BIOE TALKS SERIES (sandwiches provided)\n\nAbstract:\nMaintai
 ning genome stability relies on cellular decision making to employ the opt
 imal DNA repair mechanism. Key inputs to these decision cascades at DNA do
 uble strand breaks (DSBs) include the stage of the cell cycle\, the chroma
 tin state surrounding a DSB\, and the nuclear subcompartment in which the 
 DSB resides. In addition\, DSBs that are inefficiently repaired can move b
 etween compartments and engage different factors that influence repair out
 come. Our team uses fission yeast and mammalian cell culture models to inv
 estigate the mechanisms underlying DSB repair outcome and efficiency. Our 
 development of cell biological and genetic assays to study steps of DSB re
 pair have revealed mechanisms that control DSB end resection\, a master re
 gulator of DSB repair mechanism choice. DSB resection promotes homology-di
 rected repair (HDR)\, primarily synthesis-dependent strand annealing in fi
 ssion yeast that involves multiple strand invasion cycles\; the number of 
 cycles dictates repair efficiency. In terms of template choice during HDR\
 , we find that the nuclear periphery enhances the stringency of repair in 
 repetitive regions of the genome. One mechanism involves the LINC complex\
 , which we suggest exerts force on DSBs to enforce stringency of homology 
 testing. Last\, we have recently made new insights into the control of a l
 ast-ditch DSB repair mechanism\, microhomology-mediated end joining\, by b
 oth the cell cycle and the LINC complex.\n\n\n\nBio and Appointments:\nPro
 fessor of Cell Biology\, Yale School of Medicine \nProfessor of Molecular
 \, Cell & Developmental Biology\, Yale University\nCo-Director\, DNA Dama
 ge and Genome Integrity Research Program and Associate Director for Basic
  Science\, Yale Cancer Center\nDirector\, Graduate Program in Translation
 al Biomedicine Co-Director\, Medical Research Scholars Program\n@luskingla
 b.bsky.social\nshe/her/hers\n\nMegan King received her B.A. in Biochemistr
 y from Brandeis University and her Ph.D. in Biochemistry and Molecular Bio
 physics from the University of Pennsylvania. During her postdoctoral train
 ing with Günter Blobel at Rockefeller University\, she discovered new mec
 hanisms for the targeting and function of integral inner nuclear membrane 
 proteins. Since joining the Cell Biology Department at the Yale School of 
 Medicine in 2009\, Megan has continued to investigate the broad array of b
 iological functions that are integrated at the nuclear envelope\, from gen
 ome integrity to nuclear mechanics to mechanotransduction. In 2018 she tea
 med up with Patrick Lusk and now co-leads the joint LusKing Lab\, which fo
 cuses on nuclear mechanics\, dynamics and quality control. Megan is a past
  recipient of the NIH Director’s New Innovator Award and has been named 
 a Searle Scholar\, an Allen Distinguished Investigator\, and a Fellow of t
 he American Society for Cell Biology.\n\n\n\nZoom link (with one-time regi
 stration for the whole series) for attending remotely: https://go.epfl.ch/
 EPFLBioETalks\n\n\nInstructions for 1st-year Ph.D. students planning to at
 tend this talk\, who are under EDBB’s mandatory seminar attendance rule:
 \nIN CASE you cannot attend in-person in the room\, please make sure to\n\
 n	send D. Reinhard a note well ahead of time (ideally before seminar day)\
 , informing that you plan to attend the talk online\, and\, during seminar
 :\n	be signed in on Zoom with a recognizable user name (not any alias maki
 ng it difficult or impossible to identify you).\n\nStudents attending the 
 seminar in-person should collect a confirmation signature after the talk -
  please print your own signature sheet beforehand (69 kB pdf available for
  download here). IMPORTANTLY: hang on to this sheet as no signature record
  is being kept by anyone else!\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://go.epfl.ch/
 EPFLBioETalks
STATUS:CONFIRMED
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