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SUMMARY:Dynamics of nuclear condensates - from proteins to mesoscale organ
 ization
DTSTART:20260203T110000
DTEND:20260203T120000
DTSTAMP:20260404T035010Z
UID:c8ffcc691ec2d8ae270779c88f880678bc8fb80926519b22ae3179bd
CATEGORIES:Conferences - Seminars
DESCRIPTION:Claire Weaver\, Department of Molecular Biology at Princeton U
 niversity\nAbstract: \n\nNuclear bodies form via biomolecular phase separ
 ation\, mediated through the multivalent properties of biomolecules concen
 trated within condensates. This process forms distinct compartments that o
 rchestrate transcription\, splicing\, and ribosome biogenesis\, coordinati
 ng a cell’s identity and function. How cells manipulate the formation an
 d dynamics of nuclear condensates is poorly understood. In this talk\, we 
 will explore 1) how transcriptional repressor condensates can be dissolved
  through ERK cell signaling\, and 2) on a systems level\, how convolutiona
 l neural networks can use images of nucleolar morphology to predict the nu
 cleolus’ functional state as a centralizing hub of ribosome biogenesis.
  \n \n\nBiography:\nClaire Weaver is a Ph.D. candidate from the Departme
 nt of Molecular Biology at Princeton University. Co-mentored by Mike Levin
 e and Cliff Brangwynne\, she is interested in phase separation’s contrib
 ution to embryogenesis and gene regulation. As an NSF GRFP fellow\, she ha
 s examined proto-vertebrate repression condensate behavior. She currently 
 studies nucleolar morphology changes with genetic perturbation\, microscop
 y\, and convolutional neural networks. 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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