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SUMMARY:BMI Distinguished Seminar // Manish Saggar: Mapping and Modeling I
 ndividual Human Brain Dynamics: From Measurement to Perturbation
DTSTART:20260909T121500
DTEND:20260909T131500
DTSTAMP:20261011T205544Z
UID:3132bfe334042a394d122ef5c5eb708b1082069fd97ce81527683590
CATEGORIES:Conferences - Seminars
DESCRIPTION:Manish Saggar\, Stanford University\nUnderstanding how psychi
 atric disorders are instantiated in the brain at the level of an individua
 l remains a fundamental challenge for human neuroscience. In this talk\, I
  will describe a computational framework that approaches this problem acro
 ss several levels—from measurement and modeling to experimental design a
 nd neurobiological validation. I will show how topological data analysis c
 an reveal the structure and dynamics of individual brain-state trajectorie
 s\, and how biophysical network models can help connect these empirical ob
 servations to underlying mechanisms. I will then discuss how naturalistic 
 experiments and data-driven approaches to psychiatric nosology can provide
  richer and more biologically grounded characterizations of individual var
 iation. Finally\, I will present emerging work using pharmacological\, neu
 rostimulatory\, and internally generated perturbations to ask a forward-lo
 oking question: can an individual’s capacity for neural change itself be
 come a measurable phenotype?\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://epfl.zoom.u
 s/j/64813563657
STATUS:CONFIRMED
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