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SUMMARY:Probing and Modulating Transcription Factor–DNA Interactions via
  Chemically Modified Proteins
DTSTART:20260519T161500
DTEND:20260519T174500
DTSTAMP:20261003T031303Z
UID:aa44491200a469399d2df5d0f4beb02c2b747e3212df56f57d6b9204
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr Muhammad Jbara (Tel Aviv University)\nChemical protein synt
 hesis provides a powerful means to prepare novel\, modified proteins with 
 atomic-level precision\, offering unprecedented opportunities to understan
 d fundamental biological processes.1 Of particular interest is gene expres
 sion\, which is controlled through interactions between transcription fact
 ors (TFs) and DNA. This presentation will highlight the power of combining
  total synthesis and late-stage transformations to generate complex\, modi
 fied proteins for deciphering the molecular roles of post-translational mo
 difications (PTMs) in TFs regulation. Specific examples will focus on the 
 synthesis of site-specifically phosphorylated and acetylated TFs\, such as
  the Myc/Max system.2\, 3 Remarkably\, these studies revealed that phospho
 rylation and acetylation patterns modulate Max–DNA interactions by alter
 ing DNA binding affinity and sequence specificity. Importantly\, such mech
 anistic insights led to the development of novel bioactive miniproteins de
 rived from Max (μMax)\, capable of inhibiting oncogene expression and can
 cer cell proliferation through antagonistic binding to target genes in can
 cer cells\, paving the way for the development of new therapeutic proteins
  targeting oncogene expression.4-6\n\n\n1. O. Harel\, M. Jbara\, Angew. Ch
 em. Int. Ed.\, 2023\, 62\, e202217716\n2. R. Nithun\, Y. Yao\, X. Lin\, S.
  Habiballah\, A. Afek\, M. Jbara\, Angew. Chem. In. Ed.\, 2023\, 62\, e202
 310913\n3. R. Nithun\, Y. Yao\, O. Harel\, S. Habiballah\, A. Afek\, M. Jb
 ara\, ACS Central Science\, 2024\, 10\, 1295–1303\n4. X. Lin\, S. Mandal
 \, R. Nithun\, R. Kolla\, B. Bouri\, H. Lashuel\, M. Jbara\, JACS\, 2024\,
  146\, 25788\n5. X. Lin\, O. Harel\, M. Jbara\, Angew. Chem. In. Ed.\, 202
 4\, 63\, e202317511\n6. O. Harel\, F. Nadal-Bufi\, R. Nithun\, Y. Yao\, A.
  Afek\, M. Vendrell\, M. Jbara\, JACS\, 2025\, 147\, 46\, 42647
LOCATION:BCH 2218 https://plan.epfl.ch/?room==BCH%202218
STATUS:CONFIRMED
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