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SUMMARY:Immune–Vascular intercellular signalling coordinates tissue plas
 ticity during adult muscle repair in Drosophila
DTSTART:20260211T100000
DTSTAMP:20260404T043350Z
UID:63b485aa54329fc124adc3fcd91c931d038274637313b87de9a6c606
CATEGORIES:Conferences - Seminars
DESCRIPTION:Hadi Boukhatmi - CNRS Rennes\nLab website\nIn skeletal muscle
 \, immune and vascular responses are essential for regeneration\, yet the 
 cellular and molecular mechanisms that coordinate their activities to rest
 ore tissue function remain unclear. Here\, using Drosophila\, we uncover a
  multi-organ signaling program that integrates muscle fibers\, macrophages
 \, vascular-like tracheal cells\, and the extracellular matrix (ECM) to dr
 ive adult skeletal muscle repair. Muscle injury induces rapid macrophage r
 ecruitment and secretion of the FGF-like ligand Branchless (Bnl)\, which a
 ctivates FGF/FGFR signalling in tracheal cells and promotes their targeted
  expansion toward damaged muscle. Concomitantly\, macrophages deposit ECM 
 components on the damaged muscle\, including Collagen IV\, forming a local
 ized microenvironment that restricts Bnl ligand diffusion and facilitates 
 directed tracheal remodelling. Genetic disruption of macrophage-derived Bn
 l or macrophage-mediated ECM deposition abolishes tracheal remodeling and 
 compromises muscle recovery. Together\, these findings reveal a previously
  unrecognized immune muscle vascular program in which macrophages coordina
 te growth factor signalling and ECM organization to shape muscle microenvi
 ronment and preserve muscle function following acute damage.
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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