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SUMMARY:SCS lectureship award - Complex-and-Diverse Compounds Lead to Micr
 obiome Sparing Antibiotics
DTSTART:20260326T161500
DTEND:20260326T171500
DTSTAMP:20260527T162755Z
UID:8225a5631443545426d32b8c653967842730de1f9020760de2e2acb2
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Paul J. Hergenrother\nAbstract : \nWe have been explori
 ng an unbiased approach to determine structural features that facilitate c
 ompound accumulation in Gram-negative bacteria\, involving the assessment 
 of accumulation of hundreds of compounds\, both natural-product-like and d
 rug-like small molecules.  The results of these experiments have led to t
 he ‘eNTRy rules’\, guidelines for predicting compound accumulation in 
 E. coli and more recently the ‘PASsagE rules’ for P. aeruginosa.  Thi
 s lecture will describe the design and synthesis of these compounds\, the 
 rules\, and their application toward a general blueprint for the developme
 nt of antibiotics with activity against Gram-negative pathogens. Most crit
 ically\, we have been working on antibacterial targets that enable selecti
 ve killing of Gram-negative pathogens over commensal bacteria.  Unlike mo
 st all approved antibiotics\, the novel antibiotics we have discovered do 
 not lead to gut dysbiosis in mice\, and also do not allow C. difficile inf
 ection to take hold after treatment.  With the many deleterious effects o
 f antibiotic-induced gut dysbiosis now recognized\, this type of “dual-s
 elective” antibiotic – selective for Gram-negative bacteria over Gram-
 positive\, and selective for pathogenic bacteria over commensals – could
  have significant benefits for patients.\n\nBiography:\nProfessor Hergenro
 ther received his B.S. in chemistry from the University of Notre Dame in 1
 994. He went on to the University of Texas at Austin and obtained his Ph.D
 . in 1999\; during this time Paul was the recipient of an American Chemica
 l Society graduate student fellowship and the Roche Award for Excellence i
 n Organic Chemistry. After an American Cancer Society post-doctoral fellow
 ship at Harvard University\, he joined the faculty at Illinois in 2001. Hi
 s research interests are in the areas of synthetic organic chemistry\, che
 mical biology\, and biochemistry.\n\nWebsite:\nHergenrother Lab | Solving 
 complex disease-driven questions | Illinois\n\n 
LOCATION:BCH 2201 https://plan.epfl.ch/?room==BCH%202201
STATUS:CONFIRMED
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