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SUMMARY:MEchanics GAthering –MEGA- Seminar: How distinct active force mo
 des shape emergent structures and dynamics in non-equilibrium fluid tissue
 s
DTSTART:20260226T130500
DTEND:20260226T140000
DTSTAMP:20260916T235710Z
UID:618cc91a52206a1709d0c5553dd0313b79defef4abdc6b1f92641bab
CATEGORIES:Conferences - Seminars
DESCRIPTION:Alessandro Rizzi (MESOBIO\, EPFL)\nAbstract: Tissue mechanical
  states are tightly regulated by biochemical processes\, and distinct mech
 anisms modulating cellular and subcellular mechanical properties are known
  to induce solid-to-fluid transitions. While increasing the magnitude of a
 ctive forces can induce such transitions\, it remains unclear how differen
 t modes of activity influence structural and dynamical features of fluid s
 tates. Here\, we investigate the effects of traction forces and junctional
  tension fluctuations on confluent tissues using a two-dimensional Active 
 Foam model. We find that the resulting fluid states exhibit striking diffe
 rences in cell geometry\, spatiotemporal correlations\, and rearrangement 
 statistics\, and we verify that cell geometry in traction-driven fluid tis
 sues quantitatively agrees with our model predictions. Despite distinct ac
 tive forces leaving identifiable structural and dynamical signatures\, the
  long-term cellular displacements can be universally described by persiste
 nt Brownian motion in a mean-field approach. This work provides a minimal 
 framework for cell motility independent of active force details as well as
  a potential method to infer the dominant activity mode based solely on ce
 llular geometry\, with applications to a broad range of tissues.\n\nBio: 
 After a Physics bachelor at the University of Milan\, I moved to Germany\,
  where I obtained a Master degree in theoretical Physics from Heidelberg U
 niversity with a thesis on stochastic dynamics in heavy-ion collisions. Si
 nce 2024\, I am working as a PhD in the group of Professor Sangwoo Kim\, M
 ESOBIO. Here I theoretically and computationally model active multicellula
 r tissues\, using concepts at the intersection of non-equilibrium physics\
 , mechanics and biology.
LOCATION:ME B1 10 https://plan.epfl.ch/?room==ME%20B1%2010 https://epfl.zo
 om.us/j/68096021948?pwd=DiE8amDIwYw1u3VtW2xWNGKtioKL2y.1
STATUS:CONFIRMED
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