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SUMMARY:ChemBio Seminar by Dr. André Nadler (Max-Planck Institute for mol
 ecular cell biology and genetics (MPI-CBG)\, Germany)
DTSTART:20260318T160000
DTEND:20260318T170000
DTSTAMP:20260501T144707Z
UID:e593365d2b0f4c60310f2220a9abbf7755c453152746effdbfed795b
CATEGORIES:Conferences - Seminars
DESCRIPTION:Title: A methodological pipeline for mechanistic lipid cell b
 iology\n\nSpeaker: \n2006-2010 PhD Thesis\, Göttingen University\n2010-2
 014 PostDoc EMBL Heidelberg\n2014-current\, Research Group Leader MPI-CBG\
 n\nAbstract: Eukaryotic cells produce over 1\,000 different lipid species
  that tune organelle membrane properties\, control signalling and store en
 ergy. Studying the biological functions of individual lipid has been chall
 enging\, owing to insufficient methodology for visualizing their intracell
 ular localization\, transport between organelles and interactions with pro
 teins. Using minimally modified lipid probes\, we set up an experimental p
 latform for mechanistic lipid cell biology. We used this approach to measu
 re transport rates for individual lipids in cellular assays and discovered
  that non-vesicular lipid transport is the primary mechanism that the cell
  uses to establish the distinct lipid compositions of organelle membranes.
  In a second line of investigation\, we mapped lipid-protein interactions 
 during lipid trafficking\, found that integral membrane protein components
  of both the MICOS and NPC complexes are positioned in highly curved membr
 anes by interactions with phosphatidylethanolamine lipids and discovered t
 he likely disease mechanism of ether lipid deficiencies. We anticipate tha
 t chemical biology approaches will become an integral component of lipid b
 iology and catalyse further discoveries.\n\nLab webpage: https://www.mpi-
 cbg.de/research/researchgroups/currentgroups/andre-nadler/research-focus
LOCATION:CO 123 https://plan.epfl.ch/?room==CO%20123
STATUS:CONFIRMED
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