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SUMMARY:Alzheimer’s Drug Discovery Foundation – Accelerating Drug Disc
 overy for Frontotemporal Degeneration| Research Funding
DTSTART;VALUE=DATE:20260511
DTSTAMP:20260403T214639Z
UID:d80eccba8df5336af5a7586ba1b4cce06f7a352ab73af3f29cd1fef0
CATEGORIES:Call for proposal
DESCRIPTION:Aim:  There are currently no FDA approved disease-modifying t
 reatments available for frontotemporal dementia (FTD)\, and symptomatic tr
 eatments only provide limited benefit for patients. Recent scientific adva
 nces have provided an increased understanding of pathogenic mechanisms und
 erlying FTD and are driving the development of potential disease-modifying
  therapies. The Alzheimer’s Drug Discovery Foundation (ADDF) and The Ass
 ociation for Frontotemporal Degeneration (AFTD) seek to accelerate this pr
 ogress by supporting innovative small molecule and biologic (antibodies\, 
 oligonucleotides\, peptides\, gene therapy etc.) drug development programs
  for FTD through this request for proposals (RFP).\n\nThe funding prioriti
 es for this RFP are:\n\n	Lead optimization of novel disease-modifying comp
 ounds\, including medicinal chemistry refinement and in vitro ADME.\n	In v
 ivo testing of novel lead compounds\, biologics\, vaccines\, or repurposed
  drug candidates in relevant animal models for pharmacokinetics\, dose-ran
 ge finding\, target engagement\, in vivo efficacy\, and/or preliminary rod
 ent tolerability studies.\n\n\nFunding:       up to $300\,000 based o
 n stage and scope of research\n\nDuration:      1 year\, with potentia
 l for follow-up funding\n\nEligibility: Funding is open to researchers and
  clinicians worldwide at academic medical centers and universities or nonp
 rofits. Industry partnerships are encouraged.\n\nHow to Apply: Application
 s are reviewed in a two-step process: Letters of Intent (LOI) are the firs
 t step\, and are submitted through the ADDF Funding Portal. ADDF’s scien
 ce team will evaluate LOIs to determine whether the proposed project is co
 nsistent with the ADDF's mission and funding priorities. LOI decisions wil
 l be sent within three weeks of submission. Step 2 is an invited full prop
 osal\, which should include a detailed project narrative\, budget and just
 ification\, and biographical information.  When formulating the budget\,
  note that the following costs are not covered: Indirect costs/Overhead\, 
 Publication costs\, Equipment\, and Travel. See the full Application Instr
 uctions for more details.\n\nDeadlines:    11 May 2026 (letter of inten
 t)\n                        20 July 2026 (full prop
 osal\, by invitation)\n\nFurther information\n\n\n	More information about 
 the program is available here\n	Detailed application instructions are here
 \n	The application portal can be found here\n	For any other questions\, pl
 ease contact the Research Office\n\n\n 
LOCATION:
STATUS:CONFIRMED
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