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SUMMARY:EPFL BioE Talks SERIES  "The Baculovirus Vector System: Old Dog\, 
 New Tricks"
DTSTART:20260323T121500
DTEND:20260323T131500
DTSTAMP:20260405T205230Z
UID:ed10910d29e8d0b987ea29357ff8afdc4214cc59ce2fc20fca35fde9
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Imre Berger\, University of Bristol (UK)\nWEEKLY EPFL BI
 OE TALKS SERIES (sandwiches provided)\n\nAbstract:\nThe Baculovirus Expres
 sion Vector System (BEVS) is a time-tested tool for producing high-quality
  recombinant proteins for many applications. We contributed the MultiBac s
 ystem\, which has become instrumental for producing large multiprotein com
 plexes for high-resolution structural and functional studies. More recentl
 y\, we engineered baculovirus to expand its utility beyond recombinant pro
 tein expression. By leveraging its massive DNA cargo capacity\, we develop
 ed CRISPR-based baculovirus vectors for efficient large DNA docking\, mult
 iplexed prime editing\, and protein/DNA co-delivery in mammalian cells\, m
 inimizing off-target effects. We used our approach in patient-derived kidn
 ey cells to correct a hereditary defect causing SRNS\, a debilitating kidn
 ey disease. New developments and applications will be discussed.\n\nBio:\n
 Imre was trained as a biochemist at Leibniz University and Medical School 
 in Hannover Germany\; MIT in Cambridge USA and ETH Zurich in Switzerland. 
 After group leader posts at ETH (2005) and EMBL (2007)\, he was appointed 
 professor of biochemistry and chemistry at the University of Bristol\, UK 
 in 2014. In 2017\, he became director of the Bristol Synthetic Biology Cen
 tre and co-director of the Bristol BioDesign Institute. Since 2019\, he ha
 s been founding and managing director of the Max Planck-Bristol Centre for
  Minimal Biology. Imre researches essential proteins in human health and d
 isease\, creates synthetic vaccines\, and pioneered synthetic viral nanosy
 stems for DNA delivery\, genome engineering and complex biologics producti
 on. The tools he developed are accelerating R&D in academia and industry w
 orldwide. He holds international patents for protein and DNA technologies\
 , has published prolifically in leading periodicals\, co-founded four biot
 ech companies\, and received numerous awards and distinctions for his inno
 vative research. In 2020\, his team discovered a druggable pocket in the S
 ARS-CoV-2 spike as well as a drug that has promise for treating COVID-19. 
 In 2022\, Imre was elected Fellow of the Academy of Medical Sciences of th
 e UK.\n\n\nZoom link (with one-time registration for the whole series) for
  attending remotely: https://go.epfl.ch/EPFLBioETalks\n\n\nInstructions fo
 r 1st-year Ph.D. students planning to attend this talk\, who are under EDB
 B’s mandatory seminar attendance rule:\nIN CASE you cannot attend in-per
 son in the room\, please make sure to\n\n	send Fiorella Ghisays a note w
 ell ahead of time (ideally before seminar day)\, informing that you plan t
 o attend the talk online\, and\, during seminar:\n	be signed in on Zoom wi
 th a recognizable user name (not any alias making it difficult or impossib
 le to identify you).\n\nStudents attending the seminar in-person should co
 llect a confirmation signature after the talk - please print your own sign
 ature sheet beforehand (69 kB pdf available for download here). IMPORTANTL
 Y: hang on to this sheet as no signature record is being kept by anyone el
 se!
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://go.epfl.ch/
 EPFLBioETalks
STATUS:CONFIRMED
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