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SUMMARY:NHC Nickel and Iron Systems for Efficient C–H Bond Functionaliza
 tion
DTSTART:20260427T161500
DTEND:20260427T170000
DTSTAMP:20260921T142726Z
UID:02523d2570e0156bf22257128eb9bf538de143daba3d54dc287d5f46
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Martin Albrecht\, Department of Chemistry\, Biochemistry
  and Pharmaceutical Sciences\, University of Bern\n \nN-heterocyclic carb
 enes have profoundly re-shaped the homogeneous catalysis landscape [1].\nW
 hile initial focus has been directed on catalysis with precious metals (an
 d has led to\nunfortunate terms like ‘super-phosphines’)\, more recent
  efforts have addressed sustainability\naspects and aimed at utilizing Ear
 th-abundant first row transition metals for catalyst\ndevelopment [2]. One
  challenge in these endeavors roots in the hard-soft mismatch of the\nofte
 n higher-valent transition metal and the carbene donor site\, which weaken
 s the stability of\nthe M–C bond and may compromise catalyst integrity. 
 We will discuss different strategies to\nmeet this challenge and to develo
 p efficient first row transition metal NHC catalysts for the\noxidation[3]
  and for (intramolecular) amination of unactivated C–H bonds [4]\, inclu
 ding the\nmechanistically informed improvement of their activity to beat c
 urrent benchmarks.\nWe thank the Swiss National Science Foundation (SNSF) 
 for continuous support of this work.\nReferences\n[1] N-Heterocyclic Carbe
 nes: From Laboratory Curiosities to Efficient Synthetic Tools\, RSC Cataly
 sis\nSeries (Ed. S. Diez-Gonzalez)\, RSC \, Cambridge\, 2017.\n[2] W. Stro
 ek\, M. Albrecht\, Chem. Soc. Rev. 2024\, 53\, 6322–6344.\n[3] G. Rigoni
 \, S. Bertini\, F. C. Bühler\, M. Albrecht\, ACS Catal. 2026\, in press (
 DOI:\n10.1021/acscatal.6c00999).\n[4] W. Stroek\, M. Keilwerth\, D. Pivido
 ri\, K. Meyer\, M. Albrecht\, J. Am. Chem. Soc. 2021\, 143\, 20157–\n201
 65. W. Stroek\, N. V. A. Rowlinson\, L. A. Hudson\, M. Albrecht\, Inorg. C
 hem. 2024\, 63\, 17134–\n17140. W. Stroek\, N. V. A. Rowlinson\, L. A. H
 udson\, M. Albrecht\, Chem. Commun. 2025\, 61\,\n15274–15277.
LOCATION:Unil - Génopode B
STATUS:CONFIRMED
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