BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Memento EPFL//
BEGIN:VEVENT
SUMMARY:Life Science Seminar: Hitoshi Kurumizaka
DTSTART:20260420T160000
DTEND:20260420T170000
DTSTAMP:20260403T222631Z
UID:cf4b0abce1cef693cad004de823b19b125222d9110d12d1ffe1d2d44
CATEGORIES:Conferences - Seminars
DESCRIPTION:Title: \nStructural molecular biology for the nucleosome as a
  regulator on genomic DNA\n\nAbstract:\nIn eukaryotic cells\, genomic DNA 
 is highly compacted into chromatin through its association with histone pr
 oteins. The fundamental unit of chromatin\, the nucleosome\, consists of ~
 147 base pairs of DNA wrapped around a histone octamer composed of H2A\, H
 2B\, H3\, and H4. These nucleosomes are connected by linker DNA\, forming 
 a “beads-on-a-string” structure that enables efficient packaging of th
 e genome.\nBeyond structural compaction\, nucleosomes play a central role 
 in regulating genome function. They can restrict access to DNA and act as 
 barriers to essential processes such as transcription\, replication\, and 
 repair. At the same time\, nucleosomes serve as key epigenetic platforms\,
  where histone modifications and histone variants modulate chromatin struc
 ture and dynamics to control gene activity.\nTo better understand these re
 gulatory mechanisms\, we employ biochemical and structural approaches to i
 nvestigate nucleosome structure and dynamics. Our studies aim to elucidate
  how structural transitions of nucleosomes influence DNA accessibility and
  ultimately govern genomic regulation. I will present our recent structura
 l and biochemical insights and discuss their implications for understandin
 g nucleosome-mediated genome regulation.\n\nBio:\nHitoshi Kurumizaka is a 
 Professor at the Institute for Quantitative Biosciences\, The University o
 f Tokyo\, Japan. After receiving his Ph.D. degree in 1995\, he started his
  postdoctoral training at NIH in the USA\, in the laboratory of Molecular 
 Embryology (Alan Wolffe Lab)\, where he began chromatin research. In 1997\
 , he joined RIKEN as a Research Scientist. He subsequently moved to Waseda
  University\, where he served as Associate Professor and later as Professo
 r of Molecular and Structural Biology. Since 2018\, he has been Professor 
 at the Institute for Quantitative Biosciences\, The University of Tokyo. H
 is research focuses on the structural basis of chromatin and epigenetic re
 gulation in eukaryotic genomes. In 2020\, he established an in-house cryog
 enic electron microscopy (cryo-EM) platform to advance high-resolution str
 uctural studies of chromatin and genome-associated protein complexes. Prof
 essor Kurumizaka has made significant contributions to the field of chroma
 tin biology through structural and mechanistic studies of nucleosomes and 
 genome-associated protein complexes. His work has been published in leadin
 g international journals and has substantially advanced our understanding 
 of chromatin architecture and epigenetic regulation.\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://epfl.zoom.u
 s/j/64667340373
STATUS:CONFIRMED
END:VEVENT
END:VCALENDAR