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SUMMARY:BMI Seminar // Use of human genome variation to invigorate  drug d
 iscovery and development
DTSTART:20130529T121500
DTEND:20130529T131500
DTSTAMP:20260428T021848Z
UID:90e40d23fddfc60f315b6c1f79608aa0d948320ec7aad80cdbc1ac80
CATEGORIES:Conferences - Seminars
DESCRIPTION:Vincent Mooser\nService de biomédecine\nUnil - Université de
  Lausanne\, Switzerland\nAbstract\nRecent discoveries of an abundance of r
 are functional variants in the human genome open up new opportunities to i
 nvigorate drug discovery and development. More specifically\, these “gif
 ts by nature” can be used for drug target identification and validation\
 , shortcutting the need to translate data from animal or cellular models i
 nto humans. Moreover\, the presence of naturally occurring functional gene
 tic variants makes it possible to contemplate a new generation of more dec
 isive\, smaller and faster proof-of-concept studies. Here\, investigationa
 l drugs are tested early in their development in individuals who have the 
 highest chance to respond to\, and benefit from the intervention\, i.e. th
 ose who carry a genetic variant which functionally mirrors the effect of t
 he intervention. The presentation will illustrate the power of these gene-
 based (i.e. Mendelian) approaches and describe the unique platform\, inclu
 ding a large biobank\, which is being constructed locally to collect tangi
 ble fruits of the “genomic revolution".
LOCATION:SV1717A
STATUS:CONFIRMED
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