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SUMMARY:From Helical Motifs to Oral Drugs: Design Principles for Bioavaila
 ble Macrocyclic Peptides
DTSTART:20260420T141500
DTEND:20260420T151500
DTSTAMP:20260403T222616Z
UID:2a253b08f9aa7ec919c642dcc9df27098129dc194674cd64aa712d0e
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Jayanta Chatterjee\, Indian Institute of Science\, Bang
 alore\, India\nIn this seminar\, I will discuss our efforts to design conf
 ormationally constrained helical macrocyclic peptides and outline the prin
 ciples that enable effective targeting of protein–protein interactions b
 eyond classical stapled peptides. In the second part\, I will show how a 
 subtle isosteric backbone modification—thioamidation—can be used to im
 part oral bioavailability to bioactive macrocyclic peptides. I will furthe
 r illustrate how conformational restriction enhances membrane permeability
  and highlight the critical role of metabolic stability in achieving oral 
 bioavailability.
LOCATION:BCH 3118 https://plan.epfl.ch/?room==BCH%203118
STATUS:CONFIRMED
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