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SUMMARY:Iridium at the Controls: Steering Selectivity toward Molecular Com
 plexity
DTSTART:20260429T171500
DTEND:20260429T180000
DTSTAMP:20260408T063051Z
UID:4239b901b578fa2174cd6eea6cb4924f840d3f36558adc942969bcda
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Fernando López\, Center for Research in Biological Chem
 istry and Molecular Materials\,  University of Santiago de Compostela\,\n
 The development of transition-metal-catalyzed C–C and C–N bond-forming
  methods that enable the efficient and stereoselective construction of val
 uable chiral skeletons remains a highly active research area\, with ample 
 opportunities for significant advances.\nIn particular\, efficient approac
 hes based on the metal-catalyzed direct addition of C–H and N–H bonds 
 across unsaturated systems (i.e.\, hydrocarbonation and hydroamination rea
 ctions) are very attractive because of their overall atom economy and the 
 structural simplicity of the required precursors.1 Despite major advances 
 over the past decades\, this field is far from mature\, and there is a par
 ticular need for new methods that offer excellent control over chemo-\, re
 gio-\, and enantioselectivity\, enabling access to products bearing highly
  challenging tetrasubstituted stereocenters and/or multiple stereocenters 
 in a fully stereoselective manner.\nIn this context\, I will summarize our
  recent efforts to harness the distinctive reactivity of iridium catalysts
  to promote asymmetric hydrocarbonation and hydroamination reactions with 
 unconventional selectivities in both intra- and intermolecular settings. T
 he application of one of these processes to natural product synthesis will
  also be highlighted.2\n\n1 a) R. Blieck\, M. Taillefer\, F. Monnier\, Che
 m. Rev. 2020\, 120\, 13545-13598. b) C. G. Newton\, S. G. Wang\, C. C. Oli
 veira\, N. Cramer\, Chem. Rev. 2017\, 117\, 8908-8976. c) S. Ma\, J. F. Ha
 rtwig\, Acc. Chem. Res. 2023\, 56\, 1565-1577.\n2 a) A. Arribas\, M. Calve
 lo\, D. F. Fernández\, C. A. B. Rodrigues\, J. L. Mascareñas\, F. López
 \, Angew. Chem. Int. Ed. 2021\, 60\, 19297. b) A. Arribas\, M. Calvelo\, A
 . Rey\, J. L. Mascareñas\, F. López\, Angew. Chem. Int. Ed. 2024\, 63\, 
 e202408258. c) A. Rey\, A. Arribas\, J. L. Mascareñas\, F. López\, Angew
 . Chem. Int. Ed. 2025\, 64\, e202512027. d) A. Arribas\, A. Rey\, M. Calve
 lo\, J. L. Mascarenas\, F. López\, Angew. Chem. Int. Ed. 2025\, e20250825
 2.
LOCATION:Unil - Genopode B
STATUS:CONFIRMED
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