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SUMMARY:Dissecting SELEX for reliable aptamers: from small molecules to mi
 croplastics
DTSTART:20260506T100000
DTEND:20260506T110000
DTSTAMP:20260526T074433Z
UID:d1cbd3b99a24d377f0fac301174df660e2e35e2c9b5d750a3928c965
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Juewen Liu\, Department of Chemistry at the University 
 of Waterloo\nBIOENGINEERING SEMINAR\n\nAbstract:\nDNA aptamers offer unpar
 alleled specificity\, stability\, and programmability for molecular recogn
 ition across diverse targets. Our lab combines the capture-SELEX method wi
 th deep sequencing to quantitative dissect the aptamer selection process f
 or various targets from metal ions\, small molecules (e.g.\, antibiotics\,
  lactate)\, proteins (e.g.\, green fluorescent proteins) to complex target
 s such as cornea tissue and microplastics. Understanding key parameters su
 ch as target concentration\, incubation time and buffer conditions (pH\, s
 alt) have yielding aptamers with nanomolar affinities and fundamental insi
 ghts regarding selection outcomes. These advances not only demystify SELEX
  but also pave the way for next-generation diagnostics\, therapeutics\, an
 d environmental monitors\, bridging molecular chemistry with real-world ch
 allenges.\n\nZoom link for attending remotely: https://epfl.zoom.us/j/668
 76869639
LOCATION:SV 1717 https://epfl.zoom.us/j/66876869639 https://epfl.zoom.us/j
 /66876869639
STATUS:CONFIRMED
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