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SUMMARY:Engineering metalloenzymes with genetic code expansion by Prof. Al
 exandria Deliz Liang (Uni Zurich) - CH-635
DTSTART:20260507T161500
DTEND:20260507T171500
DTSTAMP:20260416T122857Z
UID:5c00bde36f3b57f0dd45ecdc322b7328be170f515780470263fe9a2f
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Alexandria Deliz Liang\nAbstract: \nMetalloenzymes are c
 ompelling targets for protein engineering. While traditional mutagenesis w
 ith the 20 canonical amino acids has enabled significant advances\, its ch
 emical scope remains limited. The incorporation of non-canonical amino aci
 ds (ncAAs) into proteins has the potential to expand the chemistry accessi
 ble through mutagenesis and enable precise control through mutations that 
 are more finely tuned than those achieved with canonical amino acid mutage
 nesis. However\, this strategy remains underexplored. To expand this poten
 tial\, we engineered new tools for the incorporation of key ncAAs and have
  applied these tools to demonstrate improved activity over several propert
 ies\, including expanding the catalytic pH range\, increasing the redox po
 tential of metallocofactors\, and accelerating the rate-limiting step of c
 atalysis. These results establish ncAA mutagenesis as valuable tool for me
 talloenzyme engineering\, capable of improvements inaccessible through can
 onical mutagenesis.\n\nSpeaker's biography: \nAlexandria (Ali) Deliz Liang
  is an assistant professor at University of Zurich. Prior to becoming an a
 ssistant professor\, Ali studied at New College of Florida and completed h
 er PhD in the laboratory of Stephen J. Lippard (MIT\, US). She conducted t
 wo postdoctoral fellowships\, first in the laboratory of Jason W. Chin (LM
 B\, UK) and then in the laboratory of Thomas R. Ward (University of Basel\
 , CH). Her laboratory focuses on research related to enzyme engineering an
 d genetic code expansion. \n\nLab's website: https://www.adl-lab.com/ali
LOCATION:BS 150 https://plan.epfl.ch/?dim_floor=1&lang=en&dim_lang=en&tree
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STATUS:CONFIRMED
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