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SUMMARY:Nanoscale analysis of membrane proteins in native milieu
DTSTART:20260707T150000
DTEND:20260707T160000
DTSTAMP:20260524T174305Z
UID:546796dd8b22c74b34d8feee7be9209ab2896d9a3a4bb710ea651579
CATEGORIES:Conferences - Seminars
DESCRIPTION:Moitrayee Bhattacharyya\, Ph.D. Assistant Professor\, Departm
 ent of Pharmacology\, Yale University School of Medicine  \nAbstract: In
  this seminar\, Moitrayee Bhattacharyya will present her lab’s work on d
 eveloping experimental platforms to resolve the molecular and functional o
 rganization of membrane proteins in their native environments and applying
  these tools to study membrane proteins that regulate neuronal signaling a
 nd neurodegeneration\, chronic pain\, and cancer. High-resolution quantita
 tive measurements of the oligomeric organization of membrane proteins in n
 ative membranes\, and how they change under different conditions\, are ind
 ispensable for understanding membrane protein biology. Her lab reported a 
 single-molecule technique\, Native-nanoBleach\, to determine the oligomeri
 c distribution of membrane proteins from native membranes at ~10 nm spatia
 l resolution and at endogenous levels of expression. They applied Native-n
 anoBleach to quantify the oligomerization status of structurally and funct
 ionally diverse membrane proteins. Her team has now extended this general 
 technique to organellar membrane proteins and membrane contact sites in th
 e context of neurodegeneration and rare developmental diseases. This gener
 al experimental pipeline will usher in a new era of studying membrane prot
 ein organization in their native membrane environments under various physi
 ological and clinical conditions.\n \nBio: Moitrayee Bhattacharyya receiv
 ed her Ph.D. in Computational Biophysics at the Indian Institute of Scienc
 e\, Bangalore\, where she used molecular dynamics simulations and network 
 theory to study allosteric communication in protein complexes. She transit
 ioned into experimental biology during her postdoctoral studies at the Uni
 versity of California\, Berkeley\, as a Human Frontiers Science Program Lo
 ng Term Fellow. Here\, she used structural biology and single-molecule mic
 roscopy to study the molecular mechanism of regulation in a calcium/calmod
 ulin-dependent protein kinase that is critical for learning and memory. Sh
 e started her lab at Yale University in the summer of 2020. One focus is t
 o develop broad-impact technological platforms that enable high-resolution
  studies of membrane proteins in native membranes\, in her lab and beyond.
  Her lab also applies these technologies in conjunction with established b
 iophysical and structural methods to understand the molecular mechanisms o
 f membrane-localized signaling in chronic pain and neurodegenerative disea
 ses.
LOCATION:Conference room SV.1717 https://www.epfl.ch/schools/sv/it/sv-room
 s/#SV1717
STATUS:CONFIRMED
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