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SUMMARY:Imaging Seminar: Mapping cellular function with 3D single-molecule
  tracking and super-resolution microscopy
DTSTART:20260625T170000
DTEND:20260625T180000
DTSTAMP:20260523T201414Z
UID:4961047c31e5567e52ed2bd441aa992555bb54996a917a68ba637131
CATEGORIES:Conferences - Seminars
DESCRIPTION:Anna-Karin Gustavsson\nRegistration\n\nAbstract: Cellular func
 tion is governed by the molecular organization and interactions at the nan
 oscale. In this talk\, I will present our recent advances in 3D single-mol
 ecule tracking of dynamics and super-resolution imaging of nanoscale struc
 tures throughout mammalian cells\, and showcase applications of our approa
 ches for cellular imaging. I will describe our developments of light sheet
  microscopy platforms that reduce fluorescence background\, photobleaching
 \, and the risk of photodamaging sensitive samples. Combined with point sp
 read function (PSF) engineering for nanoscale localization of individual m
 olecules in 3D\, deep learning for analysis of overlapping emitters\, and 
 a novel 3D nanoprinted microfluidic chip for environmental control\, these
  platforms enable whole-cell multi-target 3D single-molecule super-resolut
 ion imaging with improved accuracy\, precision\, and imaging speed. I will
  also highlight our recent developments and applications of dCas9-based la
 bels that enable flexible\, long-term tracking of endogenous\, non-repetit
 ive genomic loci in live human cells with excellent spatiotemporal resolut
 ion. Using this approach\, we demonstrate correlative tracking of gene dyn
 amics and transcription for improved understanding of gene regulation. I w
 ill further showcase studies of disease mechanisms and novel therapies for
  the premature aging disorder Hutchinson-Gilford Progeria Syndrome. Togeth
 er\, these imaging technologies provide a versatile toolkit for quantitati
 ve studies of molecular dynamics\, nanoscale structures\, and molecular me
 chanisms\, enabling new insights into a broad range of chemical\, biologic
 al\, and biomedical questions related to cellular function and pathogenesi
 s.\n\nBio: Dr. Gustavsson joined the faculty at Rice University in 2020 a
 s a CPRIT Scholar in Cancer Research and the Norman Hackerman-Welch Young 
 Investigator Chair. At Rice\, she founded and serves as Director of the Ce
 nter for Nanoscale Imaging Sciences. Her research group strives to gain de
 tailed information about cellular nanoscale structures\, dynamics\, and mo
 lecular mechanisms by designing and applying innovative and versatile opti
 cal imaging tools. Dr. Gustavsson received her Ph.D. in Physics from the U
 niversity of Gothenburg\, Sweden. Her graduate work focused on studying rh
 ythms and dynamic responses in single cells by combining and optimizing te
 chniques such as fluorescence microscopy\, optical tweezers\, and microflu
 idics. Upon completion of her graduate work\, Dr. Gustavsson joined the
  group of Nobel Laureate W. E. Moerner at Stanford University as a Postdoc
 toral Fellow. Her research focused on the development and application of 
 3D single-molecule super-resolution microscopy for cellular imaging and in
 cluded the implementation of light sheet illumination for optical sectioni
 ng of mammalian cells. Her work has been recognized with multiple honors\
 , awards\, and fellowships\, most notably the FEBS Journal Richard Perham
  Prize\, the 3-year Swedish Research Council International Postdoctoral F
 ellowship\, the PicoQuant Young Investigator Award\, the NIH K99/R00 Pat
 hway to Independence Award\, the CPRIT Recruitment of First-Time Tenure-T
 rack Faculty Members Award\, the Scialog: Advancing Bioimaging Fellowship\
 , the Edward S. and Fofo Lewis Chemistry Research Award\, the NIH Maximi
 zing Investigators' Research Award (MIRA)\, and the NSF CAREER Award.\n\nT
 he seminar is followed by an aperitif. 
LOCATION:BM 5202 https://plan.epfl.ch/?room==BM%205202
STATUS:CONFIRMED
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