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SUMMARY:Bacterial Immune Systems: From Molecular Mechanisms to Next-Genera
 tion Biotechnology
DTSTART:20260526T121500
DTEND:20260526T131500
DTSTAMP:20260526T170123Z
UID:1149449824307848b3cc1b62589466f8d3d0acd73ffa2433911739de
CATEGORIES:Conferences - Seminars
DESCRIPTION:Jack Bravo\, Institute of Science and Technology Austria (IST
 A)\nImmense evolutionary pressure has driven bacteria to innovate a divers
 e arsenal of immune systems that defend against parasitic mobile genetic e
 lements\, including bacteriophages and plasmids. The study of these system
 s has proven extraordinarily fruitful for biotechnology: CRISPR-Cas9\, ori
 ginally discovered as a bacterial defense mechanism\, has revolutionized g
 enome editing and demonstrated the transformative potential of mining bact
 erial immunity for molecular tools.\nYet the diversity of bacterial defens
 e extends far beyond CRISPR. Bacteria have evolved numerous strategies to 
 recognize and destroy foreign DNA\, many of which remain poorly understood
  at the mechanistic level. A central question is how these systems disting
 uish self from non-self — and how the underlying molecular logic of DNA 
 targeting is encoded in protein structure and biochemistry. We combine cry
 o-electron microscopy\, quantitative biochemistry\, and in vivo genomics t
 o characterize newly discovered defense systems and dissect their targetin
 g mechanisms. This work is revealing unexpected principles of foreign DNA 
 recognition\, with implications both for our understanding of bacterial im
 munity and for the development of next-generation biotechnological tools f
 or genome editing and beyond.
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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