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SUMMARY:Microfluidics: a tool to design active materials
DTSTART:20130108T133000
DTSTAMP:20260406T050812Z
UID:9e4080236c67d71cd45a621ab9d279d553bc5fd267a02b339483972c
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr. Esther Amstad\, Harvard University\nMicrofluidic technique
 s enable the assembly of different types of fluids into highly monodispers
 e single\, double and multiple emulsions. Depending on the composition of 
 the different types of fluids\, single emulsions can be converted into mon
 odisperse microparticles\, double emulsions into capsules. This renders mi
 crofluidic techniques attractive tools to design functional materials. The
 y are particularly well suited to assemble delivery vehicles as the thickn
 ess and composition of the shell of these vehicles can be closely controll
 ed. Furthermore\, encapsulants can be loaded into their core or shell with
  100% efficiency. However\, the assembly of monodisperse capsules that all
 ow close control over the release of encapsulants without inducing signifi
 cant changes in the environmental conditions such as temperature or pH is 
 still a major challenge. I will present the assembly of thermo- and photo-
 responsive polymersomes\; these vesicles allow triggered and selective rel
 ease of encapsulants and are therefore attractive delivery vehicles. Micro
 fluidics also allows the formulation of encapsulants\; I will introduce a 
 microfluidic spray drier that enables the formulation of hydrophobic drugs
  as nanoparticles with diameters below 30 nm. The formulation of these poo
 rly water soluble active ingredients as nanoparticles increases their diss
 olution rate and saturation concentration in water and therefore their bio
 availability.
LOCATION:MXF 1 https://plan.epfl.ch/?room==MXF%201
STATUS:CONFIRMED
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