BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Memento EPFL//
BEGIN:VEVENT
SUMMARY:Learning the Regulatory Genome by Destruction and Creation
DTSTART:20260615T140000
DTEND:20260615T153000
DTSTAMP:20260610T215111Z
UID:e47e562b051c9cf7f91c890657857fc9ec5db1d51b615222df2db4a4
CATEGORIES:Conferences - Seminars
DESCRIPTION:Luca Pinello\, PhD. Associate Professor\, MGH/Harvard Medical
  School and Broad Institute of Harvard and MIT\nThe regulatory genome enco
 des a complex language that determines when and where genes are expressed\
 , yet reading and writing this language remains a central challenge in gen
 omics.\n\nTwo complementary approaches — CRISPR-CLEAR\, a dense base-edi
 ting method that pinpoints individual nucleotides controlling gene activit
 y\, and DNA-Diffusion\, a generative AI framework that designs entirely ne
 w cell-type-specific regulatory elements — offer powerful new ways to de
 code and engineer this language. Together\, they have yielded clinically r
 elevant discoveries\, including noncoding variants driving CAR-T resistanc
 e in leukemia\, and point toward a future of agentic AI that allows resear
 chers to interrogate the regulatory genome in plain language.
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
END:VEVENT
END:VCALENDAR