BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Memento EPFL//
BEGIN:VEVENT
SUMMARY:Physiology-driven neuromodulation therapies to restore mobility in
  advanced Parkinson’s Disease
DTSTART:20260923T170000
DTEND:20260923T180000
DTSTAMP:20260923T110451Z
UID:f92ccb90495b37c3b9aad15f9314d0d1905bbe55222afdedddcd6012
CATEGORIES:Inaugural lectures - Honorary Lecture
DESCRIPTION:Prof. Eduardo Moraud\nPlease note that in-person attendees rmu
 st register by September 17th to access the conference room\n\n\nDespite m
 ajor advances in therapies for Parkinson’s disease\, a majority of indiv
 iduals in advanced stages experience persistent mobility impairments\, inc
 luding gait and balance deficits\, that markedly increase the risk of fall
 s and profoundly restrict independence\, social participation\, and qualit
 y of life. Unlike cardinal symptoms such as rigidity and tremor\, which ar
 e comparatively well understood and effectively treated\, locomotor defici
 ts remain poorly responsive to existing therapies. This limited efficacy r
 eflects the involvement of distinct motor\, sensory\, and postural control
  circuits underlying locomotion\, which are further modulated by attention
 al and cognitive processes during complex everyday behaviors. As a result\
 , locomotor deficits continuously fluctuate with ongoing mobility demands\
 , environmental context\, and physiological state\, while evolving over ti
 me with disease progression.\nRestoring mobility therefore requires a new 
 generation of physiology-driven neuromodulation therapies capable of ident
 ifying and selectively targeting the neural circuits that underlie locomot
 ion\, while dynamically adapting stimulation to changing motor requirement
 s\, behavioral context\, and physiological fluctuations. Targeted closed-l
 oop neuromodulation across multiple sites of the locomotor neuraxis\, incl
 uding deep brain and spinal circuits\, offers a promising framework to ach
 ieve this goal. Combining anatomical\, electrophysiological\, and computat
 ional investigations across animal models of parkinsonianism and patients 
 implanted with next-generation implantable neurostimulators\, we are ident
 ifying\, predicting\, and modulating pathological neural signatures associ
 ated with gait dysfunction during natural behaviors. These developments ar
 e establishing an integrative pipeline for physiology-driven neuromodulati
 on therapies capable of restoring mobility and independence in people with
  Parkinson’s disease.\n\nIn this talk\, Prof. Moraud will present recent
  advances toward personalized neuromodulation therapies to restore mobilit
 y in advanced Parkinson’s disease.
LOCATION:Campus Biotech Geneva B1.06 https://plan.epfl.ch/?room==B1%206%20
 272.043 https://epfl.zoom.us/j/66009438886
STATUS:CONFIRMED
END:VEVENT
END:VCALENDAR