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VERSION:2.0
PRODID:-//Memento EPFL//
BEGIN:VEVENT
SUMMARY:EPFL BioEngineering Talks
DTSTART:20260907T121500
DTEND:20260907T134500
DTSTAMP:20260921T010155Z
UID:ff56d8c17802b41c7fe6d6baa65ba0b3b3fc684ab7cb9eeb1d046bb4
CATEGORIES:Conferences - Seminars
DESCRIPTION:Invited Speaker and Student Speaker\nWeekly BioEngineering Tal
 ks ( Lunch Provided)\n\nINVITED SPEAKER:\n\nFinding New Drugs in Trillions
 : ICM Docking\, GPUs\, Pocketome\, and Design Strategy\nProf. Ruben Abagy
 an\, University of California\, San Diego on sabbatical at EPFL\n\nAbstra
 ct:\nAccurate docking and scoring of a flexible compound to the most suita
 ble mutant\, conformational and functional state of the primary target\, a
 nd definition of essential selectivity and property requirements is the fi
 rst step in structure-guided drug discovery. We will discuss ultra large d
 ocking screens and compound-growth strategies\, and ways to dramatically a
 ccelerate algorithms using GPUs. Several applications of this pipeline to 
 lead discovery projects in cancer and neurodegenerative diseases\, with so
 me in clinical trials\, will be presented.\n\nBio:\nRuben Abagyan is Profe
 ssor at the UCSD Skaggs School of Pharmacy and Pharmaceutical Sciences and
  founder of MolSoft. He pioneered mathematical frameworks for protein fold
 ing and flexible ligand docking during his time at EMBL in Heidelberg. His
  career includes notable roles as tenured Associate Professor at NYU's Ski
 rball Institute and Courant Institute of Mathematics\, Director at Novarti
 s Institute in La Jolla\, and Professor at Scripps Research Institute. Rec
 ognized with the Princess Diana award for structure-based ligand discovery
  and other awards\, he now leads research on drug discovery projects\, Poc
 ketome\, 3D/AI/ML models for predictive pharmacology\, and fast docking sc
 reens of ultra-large chemical spaces. With over 330 publications and paten
 ts\, 50\,000 citations\, and an H-index of 105\, he continues to advance m
 ethodology and collaborate with colleagues in computational science\, biom
 edicine\, and chemistry\, to discover drug candidates.\n\nSTUDENT SPEAKER:
 \n\nChallenging Anfinsen’s dogma with protein design\nChristian Schellha
 as\, Correia Lab\n\n\n---------------------------------------------------
 ----------------------\n\nBioEngineering Talks mandatory EDBB Seminar Atte
 ndance (1st-Year PhD Students)\n\n	 Attendance sheet to print HERE \n\nT
 he BioEngineering Student Seminar Series is an official course for which s
 tudents can register and earn credits\n \n\n	Register HERE\n	Attendance s
 heet to print HERE\n\nGeneral information:\nIn-person attendance is prefer
 red to support your fellow students. Zoom is mainly for students on remote
  campuses\; please notify Fiorella Ghisays in advance and join using your 
 full name.\nIf attending in person\, have your sheet signed after the talk
  and keep the original\, as no copy is retained.\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://epfl.zoom.u
 s/j/68746410793
STATUS:CONFIRMED
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