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SUMMARY:Lysosomes at the nexus of cellular quality control and metabolism
DTSTART:20261014T160000
DTEND:20261014T170000
DTSTAMP:20260920T144923Z
UID:be6103af106ce803058e4fa2c3f3a10852d790e5309b47cf0e0bb416
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr. Aakriti Jain\, UTSW\nLysosomes sit at the crossroads of ce
 llular catabolism and quality control\, where they must dismantle chemical
 ly diverse cargo while preserving their own integrity. I will discuss two 
 discoveries that reveal how lysosomes solve these complementary challenges
  and how their failure creates disease vulnerabilities. First\, I will des
 cribe Lysosomal Leucine Aminopeptidase (LyLAP)\, an enzyme specialized to 
 processively degrade the hydrophobic α-helices of transmembrane proteins.
  LyLAP is highly expressed in pancreatic ductal adenocarcinoma\, where its
  loss causes hydrophobic peptides to accumulate\, compromises lysosomal fu
 nction\, and ultimately leads to cancer cell death\, revealing a potential
  vulnerability in tumors with elevated endocytic activity. I will then des
 cribe LASER\, a damage-responsive protein assembly that couples lysosomal 
 membrane injury to repair. At its core\, the oligomeric protein TFG recogn
 izes LC3/GABARAP proteins conjugated to damaged lysosomes and recruits the
  ESCRT machinery to restore membrane integrity. Neurodegenerative disease-
 associated mutations in TFG disrupt this process\, linking defective lysos
 omal repair to human disease. Together\, these findings reveal lysosomes a
 s dynamic systems that coordinate cargo degradation with membrane surveill
 ance and repair to maintain cellular homeostasis. \n\nMore about Dr. Aakr
 iti Jain's lab at UTSW: https://aakritijainlab.com/
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://epfl.zoom.u
 s/j/7467019292
STATUS:CONFIRMED
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