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SUMMARY:Chemical tools for investigating histone deacetylases (HDACs)
DTSTART:20260918T161500
DTEND:20260918T180000
DTSTAMP:20261003T021802Z
UID:ddbfae5ce18bf3c078d364728ca8dc86534ec9901f40bb2852116886
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Christian Olsen (Copenhagen University)\nHistone deacet
 ylases (HDACs) are validated targets for treatment of certain cancer types
  and play numerous regulatory roles in biology\, ranging from epigenetics 
 to metabolism. Small molecules are highly important as tool compounds to p
 robe these mechanisms as well as for the development of new medicines. The
 refore\, detailed mechanistic information and precise characterization of 
 the enzyme substrate preference as well as development of chemical probes 
 to investigate the effects of HDAC enzymes are vital.\nThrough profiling o
 f both sirtuins and zinc-dependent HDACs\, we have developed efficient ass
 ay formats for inhibitor characterization and discovered enzymatic activit
 ies against novel e-N-acyllysine posttranslational modifications\, most re
 cently e-N-lactyllysine.\nIn this presentation\, I will focus on our advan
 ces in the selective targeting of SIRT5\, SIRT7 and HDAC11\, using differe
 nt strategies including covalent targeting and macrocyclic peptide inhibit
 ors.\n 
LOCATION:BCH 2218 https://plan.epfl.ch/?room==BCH%202218
STATUS:CONFIRMED
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