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SUMMARY:Neuro-X seminar: Prof Tomoya Duenki - Emergent Neural Dynamics in 
 Scalable Brain Organoid Networks
DTSTART:20260921T110000
DTEND:20260921T120000
DTSTAMP:20261001T041938Z
UID:a29940b3ecda70509bc8ccd35e0615110f9e931ab2de0a4d63bd0955
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof Tomoya Duenki\nReconstructing physiologically relevant n
 euronal networks in vitro is essential for advancing our understanding of 
 brain development\, function\, and disease. Human cerebral organoids provi
 de a promising platform\, but conventional systems remain limited in struc
 tural complexity\, connectivity\, and scalability for studying large-scale
  neural dynamics. To address these limitations\, we engineered modular org
 anoid networks\, termed “connectoids\,” in which multiple organoids ar
 e connected through guided axon bundles using microfluidic devices. Electr
 ical recordings revealed that increasing network size from single organoid
 s to multi-organoid connectoids resulted in progressively more complex neu
 ral dynamics\, including prolonged activity periods\, richer and more dive
 rse bursting patterns\, the emergence of functionally specialized network 
 nodes\, and network states approaching criticality. Pharmacological pertur
 bations confirmed robust excitatory and inhibitory network responses\, whi
 le optogenetic and electrical stimulation demonstrated controllable propag
 ation and entrainment of activity across the network. Together\, these sca
 lable connectoid systems provide a platform for investigating emergent neu
 ral dynamics\, structure–function relationships\, and circuit organizati
 on across different levels of network complexity.
LOCATION:B1-6 https://plan.epfl.ch/?room==B1%206%20272.043 https://epfl.zo
 om.us/j/68031399127?pwd=fnblK0L1HtnGjYIDQucaGE88xDsQI1.1
STATUS:CONFIRMED
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