BEGIN:VCALENDAR VERSION:2.0 PRODID:-//Memento EPFL// BEGIN:VEVENT SUMMARY:EPFL BioEngineering Talks DTSTART:20261005T121500 DTEND:20261005T134500 DTSTAMP:20261006T011547Z UID:21b6dcb4091e10c3e4d3080f3891aa87b08986fc9d42f32ce16e93d4 CATEGORIES:Conferences - Seminars DESCRIPTION:Invited Speaker and Student Speaker\nWeekly BioEngineering Tal ks (Lunch Provided)\n\nINVITED SPEAKER:\n\nBuilding Time: Switching Circad ian Clock Complexes through Clustered Hyperphosphorylation of Intrinsicall y Disordered Regions\nProf. Michael Brunner\, Heidelberg University Bioch emistry Center (BZH)\nHost: Prof. Felix Naef\n\nAbstract:\nCircadian cloc ks generate ~24 h rhythms through delayed negative feedback\, yet how prog ressive phosphorylation of clock proteins is translated into temporally or dered molecular events remains incompletely understood. In the mammalian c lock\, PERIOD (PER) proteins form complexes with CRYPTOCHROME (CRY) and ca sein kinase 1δ (CK1δ) and undergo extensive phosphorylation within intri nsically disordered regions over the circadian cycle.\nWe identify a molec ular principle by which progressive phosphorylation can generate distinct and persistent regulatory states. Whereas individual phosphosites are rapi dly dephosphorylated\, multisite phosphoclusters within disordered regions of PER2 become resistant to phosphatases and display switch-like\, all-or -none phosphorylation. Distinct phosphoclusters\, including the FASP regio n\, the β-TrCP phosphodegron\, and a C-terminal phosphocluster\, exhibit markedly different dephosphorylation kinetics.\nTogether\, these findings suggest that progressive phosphorylation of intrinsically disordered PER2 is decoded by phosphoclusters that function as molecular switches with dis tinct kinetic properties. Their sequential accumulation may generate a ser ies of metastable functional states\, thereby translating progressive phos phorylation into circadian control of subunit remodeling\, subcellular loc alization\, and turnover of repressor complexes.\n\nBio:\nMichael Brunner is Professor of Biochemistry at Heidelberg University and a leading resear cher in the molecular mechanisms of circadian clocks. He received his PhD from Heidelberg University in 1989\, followed by postdoctoral research wit h James E. Rothman at Princeton University and the Sloan Kettering Institu te\, and with Walter Neupert at Ludwig Maximilian University of Munich. Du ring this time\, he made important contributions to mitochondrial biology\ , particularly to elucidating the molecular machinery responsible for mito chondrial protein import. He joined the Heidelberg University Biochemistry Center (BZH) as a professor in 2000 and has served several terms in its a cademic leadership\, including as Director of the BZH. He is currently Edi tor-in-Chief of FEBS Letters.\n\nBrunner’s research has contributed to o ne of the most complete molecular descriptions of biological timekeeping i n any organism. Using the filamentous fungus Neurospora crassa\, his labor atory has elucidated central features of the circadian feedback loop\, inc luding the functions of the White Collar Complex and FREQUENCY\, and the r oles of casein kinase 1\, progressive phosphorylation\, and dynamic comple x remodelling in determining circadian period and timing. In parallel\, hi s group has extended this work to human cells\, investigating the coordina tion of the circadian clock with the cell cycle and cellular proliferation . Notably\, this research has revealed mechanisms through which oncogenic pathways such as MYC can suppress the molecular clock and promote prolifer ation\, thereby linking circadian regulation to malignant growth. His broa der work examines how circadian systems respond to environmental and metab olic signals and how clock function may influence cancer biology and treat ment.\n\nSTUDENT SPEAKER:\n\nFluidFM: A new tool for Lipid Droplet researc h\nGeoffray Marie-Devillard\, Deplancke Lab\n\n\n------------------------ ------------------------------------------------------\n\nBioEngineering T alks mandatory EDBB Seminar Attendance (1st-Year PhD Students)\n\n  Atten dance sheet to print HERE \n\nThe BioEngineering Student Seminar Series i s an official course for which students can register and earn credits.\n  \n\n Register HERE\n Attendance sheet to print HERE\n\nGeneral information :\nIn-person attendance is preferred to support your fellow students. Zoom is mainly for students on remote campuses\; please notify Fiorella Ghisay s in advance and join using your full name.\nIf attending in person\, have your sheet signed after the talk and keep the original\, as no copy is re tained.\n  LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://epfl.zoom.u s/j/68746410793 STATUS:CONFIRMED END:VEVENT END:VCALENDAR