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SUMMARY:Gentle and Robust Dyes for Dynamic Super-Resolution Imaging
DTSTART:20261012T141500
DTEND:20261012T151500
DTSTAMP:20261007T034752Z
UID:be176dfcf31f6f07ca576b3ff8dbf0c5adf491632555974062a830d6
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr. Zhixing Chen\, Associate Professor\, College of Future Te
 chnology\, Peking University\nAbstract:\n\nLive-cell imaging technology is
  advancing into the era of dynamic super-resolution imaging of organelles 
 and specific proteins\, placing new demands on the optical properties of f
 luorescent probes. Traditional live-cell fluorescent probes face two criti
 cal technical challenges:\n\n	How to make fluorescent probes brighter and 
 more photostable.\n	How to make fluorescent probes gentler to minimize the
  photodamage of organelles.\n\nBased on the fundamental principles of phot
 ochemistry and biochemistry\, we have developed a new generation of live-c
 ell imaging probes that far surpass traditional probes in brightness\, pho
 tostability\, and biocompatibility. These probes enable long-term super-re
 solution imaging of mitochondria\, insulin vesicle secretion\, plasma memb
 rane dynamics\, lysosomes\, and more. Our representative achievements incl
 ude: The PK Mito and PK Zinc dye series\, widely used in mitochondrial and
  insulin secretion imaging. The BD series of novel fluorophores\, in conju
 nction with self-labeling tags\, offer general protein labeling strategie
 s with superior optical properties compared to fluorescent proteins.\n\n==
 ================================================\n\nBrief Biography:\n\nDr
 . Zhixing Chen\, Associate Professor\nCollege of Future Technology\nPeking
  University\n\nDr. Zhixing Chen is a tenured associate professor at the Co
 llege of Future Technology\, Peking University. He received his BS from Ts
 inghua University in 2008 and his PhD from Columbia University in 2014. He
  subsequently completed postdoctoral training at Columbia University in 20
 15 and at Stanford University from 2016 to 2018.\nThe Chen Lab at Peking U
 niversity was established in 2018. The lab endeavors to integrate chemistr
 y and biochemistry to develop new imaging tools with high brightness\, spe
 cificity\, and biocompatibility\, with the goal of advancing bioimaging te
 chnologies and enabling new approaches in cell biology\, metabolism\, and 
 biophysics.\n\nWebsite: https://zhixingchenlab.mysxl.cn/
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STATUS:CONFIRMED
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