BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Memento EPFL//
BEGIN:VEVENT
SUMMARY:EPFL BioEngineering Talks
DTSTART:20261116T121500
DTEND:20261116T134500
DTSTAMP:20261023T214746Z
UID:20b397990ff1747778d128f4182b2be07dd7313eb848bf8b7d8d98f7
CATEGORIES:Conferences - Seminars
DESCRIPTION:Invited Speaker and Student Speaker\nWeekly BioEngineering Tal
 ks (Lunch Provided)\n\nINVITED SPEAKER:\n\nMolecular timekeeping in neuron
 s: protein turnover\, synaptic maintenance\, and brain aging\nProf. Eugeni
 o Fornasiero\, University Medical Center Göttingen\nHost: Prof. David S
 uter\n\nAbstract:\nNeurons are among the longest-lived cells in our body\,
  yet they continuously renew their molecular components while preserving h
 ighly specialized structures and functions over a lifetime. How neurons ba
 lance molecular renewal with long-term stability remains one of the fundam
 ental questions in cell biology.\nIn this seminar\, I will discuss our eff
 orts to uncover the principles of neuronal molecular maintenance by studyi
 ng the dynamics\, regulation\, and spatial organization of proteins. Using
  quantitative approaches to measure protein turnover at the proteome scale
 \, we reveal how the lifetime of neuronal proteins contributes to the pres
 ervation of synaptic identity and how these processes are altered during a
 ging. I will further discuss how phosphorylation dynamics add an additiona
 l regulatory layer\, controlling protein states and functional transitions
  within neuronal systems.\nTo understand how molecular dynamics translate 
 into cellular architecture\, I will present our development and applicatio
 n of advanced imaging approaches\, including super-resolution microscopy a
 nd SUM-PAINT\, to map the nanoscale organization of synaptic proteins with
  molecular precision.\nTogether\, these approaches reveal neurons as dynam
 ic molecular systems\, where time\, space\, and regulation are integrated 
 to maintain synaptic function across the lifespan. Understanding these pri
 nciples may provide new perspectives on why neuronal maintenance fails dur
 ing aging and neurodegeneration.\n\nBio:\nBachelor and Master in Medical B
 iotechnology\; University of Modena\, Italy\, 2000 – 2005\nPh.D. in Cell
  and Molecular Biology\; San Raffaele\, Milan\, Italy and VIB\, Leuven\, B
 elgium\, 2010\nPostdoctoral fellow at San Raffaele Institute\, Milan\, Ita
 ly with Prof. Flavia Valtorta\, 2010 – 2012\nIndependent Group Leader in
  the Department of Neuro-sensory Physiology\, University Medical Center\, 
 Göttingen\, Germany\, since 2019\n\nSTUDENT SPEAKER:\n\nPhysiological res
 ponses of Clostridioides difficile to colonic mechanical force\nPo-Long Hs
 iao\, Persat Lab\n\n\n---------------------------------------------------
 ---------------------------\n\nBioEngineering Talks mandatory EDBB Seminar
  Attendance (1st-Year PhD Students)\n\n	 Attendance sheet to print HERE 
 \n\nThe BioEngineering Student Seminar Series is an official course for wh
 ich students can register and earn credits.\n\n\n	Register HERE\n	Attendan
 ce sheet to print HERE\n\nGeneral information:\nIn-person attendance is pr
 eferred to support your fellow students. Zoom is mainly for students on re
 mote campuses\; please notify Fiorella Ghisays in advance and join using y
 our full name.\nIf attending in person\, have your sheet signed after the 
 talk and keep the original\, as no copy is retained.\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://epfl.zoom.u
 s/j/68746410793
STATUS:CONFIRMED
END:VEVENT
END:VCALENDAR