BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Memento EPFL//
BEGIN:VEVENT
SUMMARY:EPFL BioEngineering Talks
DTSTART:20261207T121500
DTEND:20261207T134500
DTSTAMP:20261023T214747Z
UID:b45029b1ef2b09d983a633b18b4ee49da8ef63540b728c92765b404f
CATEGORIES:Conferences - Seminars
DESCRIPTION:Invited Speaker and Student Speaker\nWeekly BioEngineering Tal
 ks (Lunch Provided)\n\nINVITED SPEAKER:\n\nIntracellular architecture and 
 mechanics: new rheostats of metastasis\nDr. Jacky Goetz\, INSERM / Univers
 ity of Strasbourg\nHost: Prof. Li Tang\n\nAbstract:\nEmerging evidence sug
 gests that the function and position of organelles\, together with their m
 echanical adaptation of cells\, are pivotal for tumor metastasis. Lysosome
 s integrate metabolic sensing with gene regulation and protease secretion\
 , while circulating tumor cells (CTCs) must adjust their mechanics to over
 come constraints during hematogenous spread. Yet\, how spatial distributio
 n of organelles and how cell-intrinsic mechanics control metastasis remain
 s elusive. Here\, we analyze lysosome subcellular distribution in patient-
 derived melanoma cells and biopsies and show that lysosome spreading scale
 s with melanoma aggressiveness\, while in parallel assessing how CTC defor
 mability affects dissemination and identifying mechanical phenotypes that 
 favor metastatic extravasation. Using chemo-genetic control of lysosome po
 sitioning\, intravital microscopy with CTC-mimicking beads\, mechanical tu
 ning in tumor lines and profiling of patient-derived cells\, we demonstrat
 e that perinuclear lysosome clustering impairs secretion\, matrix degradat
 ion and invasion\, and that the mechanical properties of circulating objec
 ts dictate their ability to enter constraining vessels. We identify cellul
 ar viscosity as a rheostat of CTC circulation\, arrest and extravasation\,
  and show that impairing lysosome spreading significantly reduces invasive
  outgrowth in mouse and zebrafish models\, with traits that favor extravas
 ation and outgrowth being partially distinct. Altogether\, these findings 
 establish lysosome positioning and CTC viscosity as key rheostats of metas
 tatic progression and suggest their potential utility for diagnosis and th
 erapeutic targeting of metastatic cancers. Whether they are interconnected
  determinants and how they control immune surveillance will be our next go
 als\n\nBio:\nJacky graduated in Pharmacology and Cell Biology from Univers
 ity of Strasbourg (France) in the laboratory of K.TAKEDA. He then moved to
  the laboratory of I.R. NABI in Montreal (University of Montreal\, Canada)
 \, and later in Vancouver (University of British Columbia\, Canada)\, wher
 e he obtained his Ph.D. in 2007. He performed two postdoctoral stays\, one
  at the CNIC in Madrid (Spain) in the laboratory of M.A. DEL POZO\, and on
 e in the lab of J.VERMOT at the IGBMC in Strasbourg (France). Fascinated b
 y tumor metastasis\, its mechanical aspects and the use of state-of-the-ar
 t microscopy approaches in several animal models\, he created the TUMOR BI
 OMECHANICS LAB in 2013. Quickly joined by a team of experts in imaging\, m
 echanobiology\, extracellular vesicles\, he built a task force aiming at f
 urther dissecting the mechanisms and mechanics of tumor dissemination. The
  team made several exciting discoveries around tumor metastasis that were 
 acknowledged by several prizes (SBCF\, Ruban Rose\, French Academy of Scie
 nces\, Fondation de France\, EuroLife). When he is not in the lab\, Jacky 
 is either running\, swimming or biking and loves competing during half Iro
 nMan triathlons (70.3). You can also find him traveling with his family\, 
 during sabbaticals (Australia\, South Africa)\, always thinking about the 
 next trip. Fascinated by Japan but also by Alsace\, where he grew up\, he 
 could « kill » for sushi and loves the alsatian architecture\n\nSTUDENT 
 SPEAKER:\n\nStructural Analysis of Intravenous Immunoglobulin (IVIG) Inter
 actions with Enteroviral Surfaces Using Cryo-EM Based Polyclonal Epitope M
 apping\nYash Garodia\, Antanasijevic Lab\n\n\n---------------------------
 ---------------------------------------------------\n\nBioEngineering Talk
 s mandatory EDBB Seminar Attendance (1st-Year PhD Students)\n\n	 Attendan
 ce sheet to print HERE \n\nThe BioEngineering Student Seminar Series is a
 n official course for which students can register and earn credits.\n\n\n	
 Register HERE\n	Attendance sheet to print HERE\n\nGeneral information:\nIn
 -person attendance is preferred to support your fellow students. Zoom is m
 ainly for students on remote campuses\; please notify Fiorella Ghisays in 
 advance and join using your full name.\nIf attending in person\, have your
  sheet signed after the talks and keep the original\, as no copy is retain
 ed.\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://epfl.zoom.u
 s/j/68746410793
STATUS:CONFIRMED
END:VEVENT
END:VCALENDAR