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SUMMARY:Building with lipids: engineering tailor-made nanostructures for d
 rug delivery
DTSTART:20261117T160000
DTEND:20261117T170000
DTSTAMP:20261109T164310Z
UID:11b4545dca09647c8bb73f4222258160401b462e39b62471c664e5c0
CATEGORIES:Conferences - Seminars
DESCRIPTION:Abstract \nIn this talk\, I will describe how we engineer lip
 id membranes as tailor-made functional materials for drug delivery. I will
  show how we develop a toolbox of biomimetic nanostructures with defined m
 embrane composition and mechanics\, characterize them biochemically and bi
 ophysically\, and link these properties to cellular uptake and cargo relea
 se.\nCentral to our work are asymmetric vesicles\, in which inner and oute
 r leaflets are controlled independently: the outer leaflet governs recogni
 tion and uptake\, while the inner leaflet protects and releases fragile ca
 rgo such as mRNA and proteins. I will close by extending this design space
  beyond lipids\, to peptide- and polymer-based architectures and hybrids t
 hereof\, and to cell-selective targeting via membrane proteomes and surfac
 e polysaccharides.\n\nSpeaker\nKevin Jahnke is physicist specializing in b
 iophysics and synthetic cell engineering\, currently leading an Emmy Noeth
 er and Max Planck Research Group at the Max Planck Institute for Medical R
 esearch in Germany. Previously\, he was a postdoctoral fellow at Harvard U
 niversity\, where he focused on engineering asymmetric lipid vesicles for 
 drug delivery\, and a visiting researcher at the University of Cambridge. 
 He received his Ph.D. in Physics from the Max Planck Institute for Medical
  Research in 2022\, following a B.Sc. and M.Sc. in Physics from Heidelberg
  University. His research combines physics\, biology\, and bioengineering 
 to develop and engineer complex synthetic cellular systems.
LOCATION:MA B1 11 https://plan.epfl.ch/?room==MA%20B1%2011
STATUS:CONFIRMED
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